Chelation: How to remove Mercury, Lead, & other Metals Description

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Glutathione (USH)
Glutathione is an important antioxidant amino acid which protects against mercury toxicity. Glutathione is a tripeptide, made from the combination of three amino acids; L-glycine, L-glutaniic acid, and L-cysteine. Studies have shown that GSH levels are decreased during cases of mercury toxicity. It is interesting to note that GSH deficiency resulting from genetic errors mimic the acute mercury toxicity effects of Minamata disease. Without adequate OSH, mercury from the environment cannot be detoxified and eliminated.

N-acetyl-L-cysteine (NAC)
This compound has been used clinically as it is able to act as a precursor to L-cysteine, cystine, L-methionine, Glutathione (USH), and mixed di-sulphides. It stimulates the body to produce large amounts of cysteine and GSH thus augmenting plasma and red blood cell contents of both cysteine and Glutathione. In experiments where animals were exposed to mercury vapour, NAC treatment increased animal survival time and decreased the mercury levels in blood, lung, and kidney tissues from these animals.

L-Methionine
L-rnethionine is an essential sulphur containing amino acid. It is used by the body to produce cysteine, cystathionine, glutathione, and taurine. Mercury is able to bind to methionine and inhibit it being used in the production of cysteine and glutathione. The addition of methionine to the diet will increase the levels of cysteine and glutathione in the body.

Methylsulfonylmethane (MSM)
This compound is a natural dietary sulphur compound that provides bioavailable sulphur. This product can provide sulphur to cysteine and methionine. MSM is a completely natural form of organic sulphur found in all living organisms and is completely free of odour or aftertaste. Mercury's great affinity for the sulphur molecule makes MSM a valuable, readily available, source of dietary sulphur. Sulphur labelled MSM has been found to be incorporated into protein cysteine residues throughout the body. MSM has also been shown to exert a beneficial effect in ameliorating a variety of allergic responses and pain associated with systemic inflammatory disorders. MSM is therefore a valuable adjunct in helping to offset the toxic effects of mercury exposure.

Pyridoxine (Vitamin B6)
Pyridoxine is critically involved in the metabolism of sulphur amino acids, and is especially critical in the conversion of one amino acid to another. Vitamin B6 is needed in the metabolic processes that convert methionine to cysteine and cysteine to glutathione. Therefore an adequate intake of Vitamin B6 will help insure the body has the necessary nutrients to produce cysteine and convert it to additional glutathione.

Zinc
Mercury is able to compete with and displace zinc in a number of biological systems. Thus mercury causes zinc deficiencies in various tissues, such as the brain. Zinc stimulates the production of metallothionein in the body, which is one way the body detoxifies the effects of mercury. Metallothionein is very rich in cysteine. Supplemental zinc is therefore vital in any mercury elimination programme.

Ascorbic Acid (Vitamin C)
Prolonged exposure to mercury tends to depress the adrenal ascorbic acid content. Providing vitamin C should help restore and/or maintain adequate adrenal levels of this critical nutrient, thus offsetting the depletion of this chemical due to stresses caused by chronic inhalation of mercury vapour.

Thiamine (Vitamin B 1)
B group vitamins are involved in energy metabolism, supporting the systems which protect against free radicals. Vitamin B I also contains a sulphur group and has been used in the treatment of mercury poisoning. Vitamin B 1 has a rapid turnover in the brain and the levels are reduced by mercury exposure through mercury oxidising thiamine to thiochrome in the brain. Symptoms of vitamin BI deficiency and mercury poisoning are very similar.

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