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Dr. Hulda's book,
The Cure for all
It is presented here as a public information service only.
All rights are reserved by the author and/or the publisher.
You can make a print or a copy of this material !
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Copyright notice: "The Cure for all Diseases"
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for non-commercial purposes provided the original copyright notice with the author's name
"The Cure for all Diseases": Copyright 1995 by Hulda Regehr Clark, Ph.D.,
All rights reserved.
Liver cleanse - Gallbladder cleanse - Liver flush
The Liver &
Gallbladder Cleanse (the Liver & Gallbladder Flush)
Pictures of Liver Flush results
Liver and Gallbladder Anatomy
Cleansing the liver of gallstones dramatically improves
digestion, which is the basis of your whole health. You can expect your
allergies to disappear, too, more with each cleanse you do! Incredibly,
it also eliminates shoulder, upper arm, and upper back pain. You have more
energy and an increased sense of well being.
|"Cleansing the liver
In medical literature, stones formed inside intrahepatic bile ducts (bile
ducts inside liver) are refrred to as "intrahepatic stones", they
are never referred to as gallstones. "Gallstones" and
"Intrahepatic" stones might be identical by consistency, but it is the
place where they are found that determines the name, not the consistency
itself, tho consistency might point to the origin of a stone. So, you
can not cleanse the liver of gallstones, you can only cleanse the liver of
Cleaning the liver bile ducts is the most powerful
procedure that you can do to improve your body's health.
But it should not be done before the parasite
program, and for best results should follow the kidney cleanse.
It is the job of the liver to make bile, 1 to 1 1/2 (one
to one and half) quarts in a day! The liver is full of tubes (biliary tubing)
(intrahepatic bile ducts) that deliver the bile to one large tube (the common bile duct). The gallbladder
is attached to the common bile duct and acts as a storage reservoir. Eating
fat or protein triggers the gallbladder to squeeze itself empty after about
twenty minutes, and the stored bile finishes its trip down the common bile
duct to the intestine.
For many persons, including children, the biliary tubing
is choked with gallstones.
|"For many persons, including children, the biliary
tubing is choked with gallstones"
This statement have
been found not to be true for many people in the western world, and may be
true for many people in Asia.
Intra-hepatic stones (IHS) have been described as early as the 16th
century; however, the first detailed description of the disease in English
literature was not until 1906.
Intra-hepatic stones are more prevalent in eastern Asia, with the
highest incidence being in Taiwan, followed by China, Hong Kong, Korea,
Malaysia and Japan. There also seems to be a high incidence in Brazil. On
the other hand, the Western world and India have a low incidence of
In the Western world, IHS is generally thought to be secondary to
stones originating in the gall bladder or primarily resulting from benign
strictures cysts or malignant biliary tumours.
In the East, however, IHS is regarded as a separate entity altogether. The
majority of IHS is associated with "recurrent pyogenic Cholangitis ” (RPC)
(bacterial infection of the biliary tract) which affects both genders
equally and has a peak incidence in the third and fourth decades of life.
It is more common among poor people and those in rural rather than urban
The diet of the Orient, predominantly high in carbohydrate and low in fat
and protein, has been implicated as an etiological factor for RPC. As
saturated fat causes the hormone cholecystokinin to be released which
contracts the gallbladder, a diet low in saturated fats could conceivably
lead to biliary stasis, predisposing to IHS. A low-protein diet is also
responsible for a decreased level of “glucaro-1.4-lactone”, leading to
formation of calcium bilirubinate stones.
Recent studies from Korea report that presently about 40%-50% of IHS are
of mixed variety, and some stones being pure cholesterol stones have lent
support to the dietary theory.
Some develop allergies or hives but some
have no symptoms. When the gallbladder is scanned or X-rayed nothing is
seen. Typically, they are not in the gallbladder. Not only that, most are
too small and not calcified, a prerequisite for visibility on X-ray.
are over half a dozen varieties of gallstones, most of which have cholesterol
crystals in them. They can be black, red, white, green or tan colored. The
green ones get their color from being coated with bile. Notice in the
how many have imbedded unidentified objects. Are they fluke remains? Notice
how many are shaped like corks with longitudinal grooves below the tops.
We can visualize the blocked bile ducts from such shapes. Other stones are
composites - made of many smaller ones - showing that they regrouped in
the bile ducts some time after the last cleanse. At the very center of each
stone is found a clump of bacteria, according to scientists, suggesting
that a dead bit of parasite might have started the stone forming.
the very center of each stone is found a clump of bacteria"
This statement has been found not to be true for most stones. Some
gallstones and some Intra-hepatic stones might contain bacteria,
but most stones don't.
As the stones grow and become more numerous the back pressure
on the liver causes it to make less bile. It is also thought to slow the
flow of lymphatic fluid. Imagine the situation if your garden hose had marbles
in it. Much less water would flow, which in turn would decrease the ability
of the hose to squirt out the marbles. With gallstones, much less cholesterol
leaves the body, and cholesterol levels may rise Gallstones, being porous,
can pick up all the bacteria, cysts viruses and parasites that are passing
through the liver. In this way "nests" of infection are formed, forever
supplying the body with fresh bacteria and parasite stages. No stomach infection
such as ulcers or intestinal bloating can be cured permanently without removing
these gallstones from the liver. For best results, ozonate the olive oil
in this recipe to kill any parasite stages or viruses that may be released
during the cleanse.
- You can't clean a liver with living parasites in it.
You won't get many stones, and you will feel quite sick.
the week before and complete
the parasite killing program before attempting
a liver cleanse. If you are on the maintenance parasite program, you
are always ready to do the cleanse.
the kidney cleanse before cleansing the liver
is also highly recommended. You want your kidneys, bladder and urinary
tract in top working condition so they can efficiently remove any undesirable
substances incidentally absorbed from the intestine as the bile is being
|3 cups of water
3 cups water ( =750
ml = 7.5 dl ) (P.S .!! 1 cup = 250 ml = 2.5 dl = 0.25 l )
||1/2 (half) cup (light olive
oil is easier to get down), and for best results, ozonate it for 20
minutes. Add 2 drops HCl.
|Fresh pink grapefruit
||1 large or 2 small, enough to squeeze
2/3 cup juice. Hot wash twice first and dry each time.
||4 to 8, to be sure you can sleep. Don't
skip this or you may have the worst night of your life!
|Large plastic straw
|| To help drink potion.
Pint jar with lid
Black Walnut Tincture, any strength
||10 to 20 drops, to kill parasites coming
from the liver.
EPSOM salts = Magnesium Sulphate = EPSOMITE = Magnesium Sulfate Heptahydrate
Choose a day like Saturday for the cleanse, since you will
be able to rest the next day. Take no medicines, vitamins or pills that
you can do without; they could prevent success. Stop the parasite program
and kidney herbs, too, the day before. Eat a no-fat breakfast and lunch
such as cooked cereal, fruit, fruit juice, bread and preserves or honey
(no butter or milk). This allows the bile to build up and develop pressure
in the liver. Higher pressure pushes out more stones.
2:00 PM. Do not eat or drink after 2 o'clock. If
you break this rule you could feel quite ill later. Get your Epsom salts
ready. Mix 4 tbs. in 3 cups water and pour this into a jar. This makes four
servings, 3/4 (three fourths) cup each. Set the jar in the refrigerator
to get ice cold (this is for convenience and taste only).
You can substitute 3
cups water used in this recipe to dissolve Epsom salt with 3 cups freshly
pressed grapefruit or orange or freshly pressed apple juice. That way you will not
feel unpleasant taste of Magnesium Sulphate
6:00 PM. Drink one serving 3/4 (three fourths cup)
of the ice cold Epsom salts. If you did not prepare this ahead of time,
mix 1 tbs. in 3/4 (three fourth) cup water now. You may add 1/8 (one eight)
tsp. vitamin C powder to improve the taste. You may also drink a few mouthfuls
of water afterwards or rinse your mouth. Get the olive oil (ozonated, if
possible) and grapefruit out to warm up.
Alternative Schedule 1: Omit the first Epsom Slats dose at 6 p.m. Take
only one dose, waiting till 8 p.m. Change nothing else. Many people still get
stones with one less dose. If you do not, do the full course next time.
"The Cure For HIV and AIDS" By Hulda Clark pg.585
8:00 PM. Repeat by drinking another 3/4 (three fourths)
cup of Epsom salts. You haven't eaten since two o'clock, but you won't feel
hungry. Get your bedtime chores done. The timing is critical for success.
9:45 PM. Pour 1/2 (half) cup (measured) olive oil
into the pint jar. Add 2 drops HCl to sterilize. Wash grapefruit twice in
hot water and dry; squeeze by hand into the measuring cup. Remove pulp with
fork. You should have at least 1/2 (half) cup, more (up to 3/4 (three fourths)
cup) is best. You may use part lemonade. Add this to the olive oil. Also
add Black Walnut Tincture. Close the jar tightly with the lid and shake
hard until watery (only fresh grapefruit juice does this).
Can you use some other freshly
pressed fruit juice?
If you are allergic to
grapefruit or if you can not get it or if you don't want to use grapefruit, you
can substituted grapefruit with any other sour fruit.
pomello, lemon, pineaplle, lime, sour apples, sour grapes, sour berries etc.
or any other sour fruit juice, if grapefruit is not available.
If grapefruit is
available, use grapefruit.
If using lemon juice, do not blend juice with oil.
Drink little oil, little juice, from 2 differnt cups.
Mixing Olive oild with lemon juice may produce gell like consistency, something
that is not very easy to swallow. It never happens with grapefruit juice!
Can you use some other oil?
You can substitute Olive
Oil with any other cold pressed oil like:
sunflower oil, corn oil, rape seed oil, walnut oil, almond oil, haselnut oil,
cashew oil, grape seeds oil, sesame seeds oil, hemp oil, flax seeds oil, and any
other natural plant oil.
Now visit the bathroom one or more time, even if it makes
you late for your ten o'clock drink. Don't be more than 15 minutes late.
You will get fewer stones.
10:00 PM. Drink the potion you have mixed. Take 4
ornithine capsules with the first sips to make sure you will sleep through
the night. Take 8 if you already suffer from insomnia. Drinking through
a large plastic straw helps it go down easier. You may use oil and vinegar
salad dressing, or straight honey to chase it down between sips. Have these
ready in a tablespoon on the kitchen counter. Take it all to your bedside
if you want, but drink it standing up. Get it down within 5 minutes (fifteen
minutes for very elderly or weak persons).
Lie down immediately. You might fail to get stones out if you
don't. The sooner you lie down the more stones you will get out.
Be ready for bed ahead of time. Don't clean up the kitchen. As
soon as the drink is down walk to your bed and lie down flat on your back with
your head up high on the pillow. Try to think about what is happening in the
liver. Try to keep perfectly still for at least 20 minutes. You may feel a train
of stones traveling along the bile ducts like marbles. There is no pain because
the bile duct valves are open (thank you Epsom salts!). Go to sleep, you may
fail to get stones out if you don't.
Next morning. Upon awakening take your third dose
of Epsom salts. If you have indigestion or nausea wait until it is gone
before drinking the Epsom salts. You may go back to bed. Don't take this
potion before 6:00 am.
2 Hours Later. Take your fourth (the last) dose of
Epsom salts. You may go back to bed again.
"The Cure For HIV and AIDS" By Hulda Clark pg.585
Alternative Schedule 2: After taking the first dose of Epsom salts in the
morning, wait two hours and take a second dose of the oil mixture (but only 1/2
cup) and go back to bed. After two more hours take another dose of Epsom salts.
This schedule can increase the number of stones you remove."
After 2 More Hours you may eat. Start with fruit
juice. Half an hour later eat fruit. One hour later you may eat regular
food but keep it light. By supper you should feel recovered.
How well did you do? Expect diarrhea in the morning. Use a
flashlight to look for gallstones in the toilet with the bowel movement.
You can use colander if you would like to collect all stones
Look for the green kind since this is proof
that they are genuine gallstones, not food residue. Only bile from the liver is
pea green. The bowel movement sinks but gallstones float because of the
cholesterol inside. Count them all roughly, whether tan or green. You will need
to total 2000 stones before the liver is clean enough to rid you of allergies or
bursitis or upper back pains permanently.
The first cleanse may rid you of them for a few days,
but as the stones from the rear travel forward, they give you the same symptoms
again. You may repeat cleanses at two week intervals. Never cleanse when you are
Sometimes the bile ducts are full of cholesterol crystals
that did not form into round stones. They appear as a ³chaff² floating on
top of the toilet bowl water. It may be tan colored, harboring millions
of tiny white crystals. Cleansing this chaff is just as important as purging
How safe is the liver cleanse?
It is very safe. My opinion
is based on over 500 cases, including many persons in their seventies and
eighties. None went to the hospital; none even reported pain. However it
can make you feel quite ill for one or two days afterwards, although in
every one of these cases the maintenance parasite program had been neglected.
This is why the instructions direct you to complete the parasite and kidney
cleanse programs first.
You have taken out your gallstones without surgery!
I like to think I have perfected this recipe, but I certainly can
not take credit for its origin. It was invented hundreds, if not
thousands, of years ago, THANK YOU, HERBALISTS!
have taken out your gallstones without surgery!"
This statement have been shown to be true for some people, and wrong for
Liver flush can help some people get their gallstones out. It works for
people with smaller gallstones and with biliary sludge, regardless of the
composition of stones.
Those who have larger gallstones,
especially gallstones larger then 1 cm (smallest diameter of a stone), more often
then not they will not succeed in getting the real gallstones out. Large
"stones" that do appear after a liver cleanse are usually created from bile,
inside intestines, and have not existed in that size or shape inside
gallbladder, or inside liver.
But, many people with larger gallstones experienced disappearance of
their symptoms after doing liver cleanse. So, while the liver cleanse may
not get the larger stones out, it may help with symptoms (gallbladder
attack) associated with large gallstones.
This procedure contradicts many modern medical viewpoints.
Gallstones are thought to be formed in the gallbladder, not the liver. They are
thought to be few, not thousands.
They are not linked to pains other than gallbladder attacks.
It is easy to understand why this is thought: by the time you have acute pain
attacks, some stones are in the gallbladder, are big enough and sufficiently
calcified to see on X-ray, and have caused inflammation there. When the
gallbladder is removed the acute attacks are gone, but the bursitis and other
pains and digestive problems remain.
The truth is self-evident. People who have had their gallbladder
surgically removed still get plenty of green, bile-coated stones, and anyone
who cares to dissect their stones can see that the concentric circles and
crystals of cholesterol match textbook pictures of "gallstones" exactly.
From "The Cure for All Advanced Cancers", p. 562.
Where to order herbs suggested by Hulda Clark? Herbal products are sold by
RBC Herbal Inc.
An excerpt from a message posted on CureZone Liver Flush Forums:
Is there really any solid evidence that
Gallstones can exit gallbladder?
If there was any solid evidence that Gallstones
can exit gallbladder, why would any doctor claim that gallstones CAN NOT exit
Fact: Some gallstones (smaller gallstones) can
Fiction: All gallstones can exit gallbladder.
Anyone believing that every stone can exit gallbladder is ignorant/uninformed or
irrational. Rare stones can be even larger then 2
inch ( 5cm ) in smallest diameter.
Fiction: Gallstones can not exit gallbladder.
Anyone believing that no stone can exit gallbladder is ignorant/uninformed or
irrational. Stones can be smaller then 2 mm in diameter, and could easily travel
through the bile ducts without any chance of causing obstruction.
Majority of gallstones starts their "life" as
a microscopic crystal of cholesterol. Very few gallstones ever get a chance to
grow larger then 2mm. Most are expelled while small as sand.
cholesterol = chole + sterol
The name originates from the Greek chole- (bile) and stereos (solid)
cholesterol = Greek for solid bile
How do we know that some gallstones can exit
It is a well documented medical phenomenon.
Obstruction of the common bile duct is often
caused by gallstones that were expelled from the gallbladder:
In patients with chronic Pancreatitis, common bile duct obstruction is reported
in 3.2-45.6% of patients; however, only 5-10% of all patients with chronic
Pancreatitis require operative decompression of the bile duct.
Passage of gallstones into the common bile duct occurs in approximately 10-15%
of patients with Gallstones. The incidence is thus related to the presence of
gallstones, which are very common (10-20% of population).
Common bile duct stone References
 Braunwald, Fauci, Kasper, Hauser, Longo, Jameson. Harrison's Principles of
Internal Medicine. 15th Edition. McGraw-Hill. 2001.
 Cotran, Kumar, Collins 6th edition. Robbins Pathologic Basis of Disease. WB
Saunders Company. 1999.
 Fletcher, D. Gallstones, In: Tjandra, JJ, Clunie GJ, Thomas, RJS (eds);
Textbook of Surgery, 2nd Ed, Blackwell Science, Asia. 2001.
 Haslet C, Chiliers ER, Boon NA, Colledge NR. Principles and Practice of
Medicine. Churchill Livingstone 2002.
 Hurst JW (Editor-in-chief). Medicine for the practicing physician. 4th
edition Appleton and Lange 1996.
 Kumar P, Clark M. CLINICAL MEDICINE. WB Saunders 2002.
 Longmore M, Wilkinson I, Torok E. OXFORD HANDBOOK OF CLINICAL MEDICINE.
Oxford Universtiy Press. 2001
 McLatchie G and LEaper DJ (editors). Oxford Handbook of Clinical Surgery 2nd
Edition. Oxford University Press 2002.
 MEDLINE Plus
 Raftery AT Churchill's pocketbook of Surgery. Churchill Livingsone 2001.
Jaundice occurs in patients with gall stones when a stone migrates from the gall
bladder into the common bile duct...
Acute pancreatitis develops in 5% of all patients
with gall stones and is more common in patients with multiple small stones, a
wide cystic duct, and a common channel between the common bile duct and
pancreatic duct. Small stones passing down the common bile duct and through the
papilla may temporarily obstruct the pancreatic duct or allow reflux of duodenal
fluid or bile into the pancreatic duct resulting in acute pancreatitis.
Let us do some math here.
20% of people may develop gallstones during their
15% of people with gallstones may experience
obstruction of the common bile duct
How many people may experience obstruction of
the common bile duct?
Answer: 3% of total population where 20% have
What about USA?
Population of USA: 300 million.
How many people may experience obstruction of the common bile duct during their
3% = 9 million people in USA will experience obstruction of the common bile duct
with gallstone(s), gallstone(s) that most likely was formed inside gallbladder,
and then was expelled, only to be stuck into the common bile duct.
Question: Do all gallstones expelled from
gallbladder end-up blocking common bile duct?
Answer: No, only gallstones that have specific
size and/or shape.
By it's size and shape, the stone must be small enough or
slim enough to pass through the cystic duct and exit gallbladder, but it should
be large enough to stuck at the sphincter of oddi, and to block the flow of
liquid bile and pancreatic juices into duodenum.
How many gallstones have that specific size
and/or shape that would allow it to exit gallbladder, but would not allow it to
pass through common bile duct or through the "sphincter of oddi"?
Nobody knows the answer to this question, of
But, we could estimate that less then 10% of all
stones would qualify. That would be of course just an estimation.
We could estimate that 90% of gallstones (or
gallbladder sand and sludge ) that exits gallbladder would not stuck in the
common bile duct, and will never be registered. It would become feces.
What does that mean?
It could mean that majority of people with
gallstones may have expelled some of their stones (or sand) at one time or
another, without ever knowing it happened. Stones pass from bile ducts into
intestines ... no pain ... no obstruction ... no symptoms ... no awareness ....
nobody knows it happened. But it could be happening every day. That is what
nature (evolution) intended for gallstones.
Remember that each stone starts as a microscopic crystal. Who
could count the number of microscopic crystals that are existing gallbladder
Why don't all stones pass?
Why don't gallbaldder get those crystals out before they become
There could be many reasons, like: the lack of
phisical activity, poor diet, stress, dehydration, being owerweight, not
drinking enough water, infection, illness, .... hundreds of oissible
What about USA?
Population of USA: 300 million.
Number of people who will develop gallstones: 20%
= 60 million.
If 90% of them expel some smaller gallstones at
one time or another during their life, then we have 54 million people who
are going to pass or have already passed gallstones, and are not aware of it!!!
54 million of people in USA may expel some smaller gallstones from their
gallbladder. 9 million people in USA will experience obstruction of the common
bile duct, obstruction caused by a gallstone small enough to exit cystic duct,
but too large to exit sphinscter of oddi..
The sphincter of oddi is situated in the upper
intestine, or duodenum, at the site where the common bile duct enters intestine.
Normally, this sphincter functions as a one-way valve to allow bile and
pancreatic secretions to enter the bowel, while preventing the contents of the
bowel from backing up into these ducts.
You can comment and debate this recipe on the
Liver Flush Debate Forum
here on CureZone.
You can get a support on the liver flushing if you access
Liver Flush Support Forum
here on CureZone.
To get support on other alternative remedies for gallstones, please access
Gallbladder Remedies Support
Forum here on CureZone.
To get a support on Gallbladder Surgery, please access
Gallbladder Surgery Support
Forum here on CureZone.
If you are looking for the
frequently asked questions
(FAQ) about the Liver Cleanse (the Liver Flush) please click here.
Return back to the Main Page of Liver Flush.
For more relevant information, please read:
Liver cleanse & Gallbladder cleanse
(Liver flush) (an alternative to gallbladder surgery)
For more relevant information, please read:
Liver cleanse & Gallbladder cleanse
(Liver flush) (an alternative to gallbladder surgery)
Liver Cleanse FAQ
Message Board Forum
Cleanse Forum Archive -- over 500 stories!
Dr. Hulda Clark Message
inserted by webmaster:
can substitute 3 cups water (=750 dl) with 3 cups freshly pressed grapefruit
juice, or freshly pressed apple juice that is used in this recipe to dissolve
Epsom salt. That way you will not feel unpleasant taste of Magnesium
Sulphate ( = Magnesium Sulfate = Epsom salt = MgSO4 + 7H2O) ]
Magnesium Sulfate used for liver cleanse
Chemical name: Magnesium Sulfate (Heptahydrate) or (Hydrated)
Chemical Formula: MgSO4 + 7H2O, Hydrated Magnesium Sulfate
Mineral: EPSOMITE (MgSO4 + 7H2O)
Other minerals: KIESERITE (MgSO4 + H2O, Hydrated Magnesium Sulfate)
Hexahydrite (MgSO4 + 6H2O)
Magnesium sulfate reduces striated muscle contractions and blocks
peripheral neuromuscular transmission by reducing acetylcholine release at the myoneural junction. In emergency care, magnesium
sulfate is used to manage seizures associated with toxemia of pregnancy. Other uses include uterine relaxation (to inhibit
contractions of premature labor), as a bronchodilator after beta-agonist and anticholinergic agents have been used, replacement
therapy for magnesium deficiency, as a cathartic to reduce the absorption of poisons from the Gl tract, and in the initial therapy
for convulsions. Magnesium sulfate is gaining popularity as an initial treatment in the management of various dysrhythmias, particularly
torsades de pointes, and dysrhythmias secondary to a tricyclic antidepressant overdose or digitalis toxicity. The drug is also
considered as a class Ila agent (probably helpful) for refractory ventricular fibrillation and ventricular tachycardia after
administration of lidocaine or bretylium doses.
Magnesium sulfate is effective for severe acute asthma treated in the emergency department
Intravenous magnesium sulfate reduces the rate of hospital admissions and improves pulmonary function in patients with severe acute asthma treated in the emergency department.
Sources of funding: Canadian Association of Emergency Physicians and National Institutes of Health.
Magnesium sulfate is used to treat pre-eclampsia, eclampsia and preterm labor.
Pre-eclampsia (also known as toxemia and Pregnancy-Induced High Blood
Pressure) consists of high blood pressure, protein in the urine and edema (swelling). It can rapidly become severe pre-eclampsia, with
very high blood pressure, visual disturbances, failing kidneys and elevated liver enzymes. In rare cases, pre-eclampsia develops into
eclampsia, where potentially fatal convulsions occur. It also can become HELLP Syndrome (hemolysis (H), which is the breaking down of
red blood cells, elevated liver enzymes (EL), and low platelet count (LP)), which is potentially fatal to both the woman and her baby or
What is Ornithine?
Also indexed as: L-ornithine-L-aspartate, Ornithine-aspartate, OA
What does it do?
Ornithine, an amino acid, is manufactured by the body when another amino acid,
arginine, is metabolized during the production of urea (a constituent of urine).
Animal research has suggested that ornithine, along with arginine, may promote
muscle-building activity in the body by increasing levels of anabolic
(growth-promoting) hormones such as insulin and growth hormone. However, most
human research does not support these claims at reasonable intake levels.1 2 3
One study that did demonstrate increased growth hormone with oral ornithine used
very high amounts (an average of 13 grams per day) and reported many
gastrointestinal side effects.4 One controlled study reported greater increases
in lean body mass and strength after five weeks of intensive strength training
in athletes taking 1 gram per day each of arginine and ornithine compared to a
group doing the exercise but taking placebo.5 These findings require independent
In clinical studies on people hospitalized for surgery, generalized infections,
cancer, trauma, or burns, supplementation with ornithine alpha-ketoglutarate has
been reported to produce several beneficial effects.6 A double-blind trial
evaluated the effects of ornithine alpha-ketoglutarate supplementation in
elderly people recovering from acute illnesses;7 those who took 10 grams of
ornithine alpha-ketoglutarate per day for two months had marked improvement in
appetite, weight gain, and quality of life compared to those taking placebo.
They also had shorter recovery periods and required fewer home visits by
physicians and nurses and needed fewer medications.
Ornithine aspartate has been shown to be beneficial in people with hepatic
encephalopathy (brain abnormalities) due to liver cirrhosis. In a double-blind
trial, people with cirrhosis and hepatic encephalopathy received either 18 grams
per day of L-ornithine-L-aspartate or placebo for two weeks.8 Those taking the
ornithine had significant improvements in liver function and blood tests
compared to those taking placebo.
Preliminary 9 and controlled 10 studies of people with severe burns showed that
supplementation with 10–30 grams of ornithine alpha-ketoglutarate per day
significantly improved wound healing and decreased the length of hospital stays.
Where is it found?
As with amino acids in general, ornithine is predominantly found in meat, fish,
dairy, and eggs. Western diets typically provide 5 grams per day. The body also
Ornithine has been used in connection with the following condition (refer to the
individual health concern for complete information):
Liver cirrhosis (hepatic encephalopathy)
Recovery from illness
Athletic performance (for body composition and strength)
Who is likely to be deficient?
Since ornithine is produced by the body, a deficiency of this nonessential amino
acid is unlikely, though depletion can occur during growth or pregnancy, and
after severe trauma or malnutrition.11
How much is usually taken?
Most people would not benefit from ornithine supplementation. In human research
involving ornithine, 5–10 grams are typically used per day, sometimes combined
Are there any side effects or interactions?
No side effects have been reported with the use of ornithine, except for
gastrointestinal distress with intakes over 10 grams per day.
The presence of arginine is needed to produce ornithine in the body, so higher
levels of this amino acid should increase ornithine production.
At the time of writing, there were no well-known drug interactions with
1. Bucci LR, Hickson JF, Wolinsky I, et al. Ornithine supplementation and
insulin release in bodybuilders. Int J Sport Nutr 1992;2:287–91.
2. Fogelholm GM, Naveri HK, Kiilavuori KT, et al. Low-dose amino acid
supplementation: no effects on serum human growth hormone and insulin in male
weightlifters. Int J Sport Nutr 1993;3:290–7.
3. Lambert MI, Hefer JA, Millar RP, et al. Failure of commercial oral amino acid
supplements to increase serum growth hormone concentrations in male
body-builders. Int J Sport Nutr 1993;3:298–305.
4. Bucci L, Hickson JF et al. Ornithine ingestion and growth hormone release in
bodybuilders. Nutr Res 1990;10:239–45.
5. Elam RP, Hardin DH, Sutton RA, et al. Effects of arginine and ornithine on
strength, lean body mass and urinary hydroxyproline in adult males. J Sports Med
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