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Interaction of silver nanoparticles with HIV-1

Forum: Colloidal Silver,  AIDS Support
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  • Image Embedded Interaction of silver nanoparticles with HIV-1 by  sunver  5 year  3,916  Colloidal Silver / AIDS Suppo
    Interaction of silver nanoparticles with HIV-1


    http://jnanobiotechnology.com/content/3/1/6



    Abstract:

    The interaction of nanoparticles with biomolecules and microorganisms is an expanding field of research. Within this field, an area that has been largely unexplored is the interaction of metal nanoparticles with viruses. In this work, we demonstrate that silver nanoparticles undergo a size-dependent interaction with HIV-1, with nanoparticles exclusively in the range of 1–10 nm attached to the virus. The regular spatial arrangement of the attached nanoparticles, the center-to-center distance between nanoparticles, and the fact that the exposed sulfur-bearing residues of the glycoprotein knobs would be attractive sites for nanoparticle interaction suggest that silver nanoparticles interact with the HIV-1 virus via preferential binding to the gp120 glycoprotein knobs. Due to this interaction, silver nanoparticles inhibit the virus from binding to host cells, as demonstrated in vitro.

    . . .



    HAADF images of the HIV-1 virus. a) HAADF image of an HIV-1 virus exposed to BSA -conjugated silver nanoparticles. Inset shows the regular spatial arrangement between groups of three nanoparticles. b) HAADF image of HIV-1 viruses without silver nanoparticle treatment. Inset highlight the regular spatial arrangement observed on the surface of the untreated HIV-1 virus. c) EDS analysis of image a) confirming the presence of Ag. The C signal comes from both the TEM grid and the virus, O, and P are from the virus, and Na, Cl, and K are present in the culture medium. Ni and Si come from the TEM grid, while Cu is attributed to the sample holder. d) Composite size distribution of silver nanoparticles bound to the HIV-1 virus, derived from all tested preparations.

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    • Re: Interaction of silver nanoparticles with HIV-1 by  #93809  5 year  2,704


      We know CS kicks butt but :) for those of us who don't have a lot of time to read, how about simplifying things. Thanks.

      99

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    • Re: Interaction of silver nanoparticles with HIV-1 by  africana  5 year  2,945
      I think that's good news, but unfortunately silver is a metal and like a metal it is toxic to the body. Yes the body does require silver but not in obsessive amounts.

      Here is a paragaph taken from mayoclinic about the effects of silver.

      Colloidal silver is not considered either safe or effective in any of the health claims manufacturers make. No studies to evaluate colloidal silver have been published in reputable medical journals. Thus, all the claims for health benefits are based on manufacturers' opinions and anecdotes.

      The Food and Drug Administration does not consider colloidal silver safe or effective to treat any disease or condition. Taking colloidal silver could have serious side effects, such as:

      Argyria — an irreversible blue-gray discoloration of your skin, nails and gums
      Seizures and other neurological problems
      Kidney damage
      Indigestion
      Headaches
      Fatigue
      Skin irritation
      Drug interactions with penicillamine, quinolones, tetracycline and thyroxine medications
      Whenever you're considering taking a new dietary supplement, two questions are key:

      Will this do what the manufacturer or advertiser claims?
      Is it safe for me?
      Your physician is your best partner to help you answer such questions. However, in the case of colloidal silver, with no reliable evidence of a benefit and lots of potential risk, it's best to leave the silver for your jewelry!


      http://www.mayoclinic.com/health/colloidal-silver/AN01682


      This is a support forum and there is a need to be balance here (just like in life there is a need to be balanced). I'm don't necessary agree entirely with the medical community, but we all must realize that there have been significant gains there as well as complete failures.

      The natural way is the best way, but unfortunately that is being corrupted to. I tell you greed is a powerful thing and I cannot believe how many people fall into that state of mind. It complete sickness. Why would anyone want to make money off of selling lies, fake cures, or harmful medicine to innocent people?

      Clearly I'm disgusted by all of this. People need to be their own doctors and take control of their health.

      However, we all need to accept welcoming information and see if it works for us or not.

      Colloidal silver does in fact do a good job, but again its a metal just like aluminum and its toxic. And that defeats the purpose of healing or curing toxins with another toxin.

      I hope I didn't spoil your post, but the damaging side of colloidal silver needs to come to post.

      People should not get one sided in finding a cure for their ailment, I know having a trouble disease is not what anyone wants, but adding other health problems into the equations as well as depression from trying to find a magical cure is only going to lead to unhappiness.

      Health in the sense of mental, emotional, spiritual, as well as physical is a lfe long journey. Its not something that is going to be achieve over night.

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      • Re: Interaction of silver nanoparticles with HIV-1 by  ino  5 year  2,651
        OK, I'll fall for it!

        My apologies to any CZ members I may anger here but I can't resist this because I am sick and tired of reading the same old crap, copied from a squillion sites accessible in the public domain.

        I don't want to read it here! I can't speak for anyone else but that's the reason I joined this forum, so I could seek advice, input if I can and get help from REAL people who are genuine, factual, open and honest and not in the back pockets of government, medical associations, pharmaceutical companies, and hopefully not have hidden agendas. I prefer to be educated instead of being brainwashed, I'm tired of that.

        I have read the same crap in the mainstream you have just posted and feel if anyone wants to hear more of the same they could look for it in the mainstream themselves.

        FDA does not consider colloidal silver safe...????
        Will this do what the manufacturer claims...????
        Is it safe for me...????
        Your physician is your best partner...????
        No reliable evidence of benefit...????

        WHAT THE...????!!! Leave me alone please!! What planet are you visiting from? I would just like to ask one thing of you...when you come here, can you leave your mainstream info outside. If I am disciplined because of this post, then so be it, I guess I will just have to find another place where I can further my education.

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        ino
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        • Re: Interaction of silver nanoparticles with HIV-1 by  dquixote1217  5 year  2,562

          I am not the moderator here, but trust me - it is not likely to be YOU who is disciplined.  Mainstream trolls on the other hand . . .

          DQ

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        • Re: Interaction of silver nanoparticles with HIV-1 by  Exploited Citizen  5 year  2,688
          I totally agree with you.
          I hate these idiots who come on here to discredit these wonderful alternatives that actually WORK, based on the opinion of corrupt government establishments.
          If we wanted to hear the opinion of the government we would go talk to the FDA.

          This is a private site, not government, so get out! We do not care about government opinions, they suck, thats why we are here.

          Silver in small amounts is NOT toxic to the body, you are lying.
          The works of Dr. Robert O Becker completely discredit the lies of yourself and your corrupt government organizations.

          He used silver to clear infections, and dramatically improve healing times.

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        • Re: Interaction of silver nanoparticles with HIV-1 by  lifesabreez  5 year  2,575
          ino,

          HOORAY fo you! DITTO and then some! Africana's lost her cookies.

          I think they got washed (and paid for) by the main stream! lol

          LB

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        • Re: Interaction of silver nanoparticles with HIV-1 by  ParaZapper  5 year  2,501
          >- I prefer to be educated instead of being brainwashed

          I agree with you, but I do think that both sides of the argument need to be discussed. That aside, I do agree that the "establishment" gives us too much b.s.

          The FDA claims that the only thing that can cure is a drug ... That is an absolute lie.

          Vitamin D ( a natural substance ) and calcium ( a natural substance ) will cure rickets. Nothing else can do this.

          Viatmin C ( a natural substance ) will cure scurvy. Nothing else can do this.

          Vitamin B1 ( a natural substance ) will cure beriberi. Nothing else can do this.

          Niacin and tryptophan will cure pellagra. Nothing else will do this.

          These are the best known examples of natural cures.

          On the other hand, antibiotics do not cure. They only slow the growth rate of certain microbes enough to allow our immune system to handle them.

          Vacines can provide immunity but at a possible cost. It is, however, our immune system that cures in this case.

          There are drugs that will cover up a symptom enough to make a person think that they are cured, but just stop taking that drug and see what happens.

          Drugs do not cure high blood pressure.

          Cholesterol reducing drugs do not cure arterial blockage. On does show some slight reduction, but a natural substance ( sodzyme ) is ten times as effective.

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      • Re: Interaction of silver nanoparticles with HIV-1 by  sunver  5 year  2,752
        The FDA is one of the most corrupt institutions on the planet. If you trusted their advice, Vioxx does not increase the risk of heart attack, Paxil is safe for your teenager, and Cipro does not cause spontaneous tendon rupture.

        You have not addressed any of the Science in the HIV-1 study I posted. Instead you have used scare tactics with cut and paste from the corrupt FDA and their war against natural medicine. Furthermore, you claim silver is a toxic metal like aluminum, which is a somewhat ridiculous comparison.

        Perhaps you have inhaled too much barium and aluminum from the chemtrails in the sky above your head. Silver is quite different from both barium and aluminum, and indeed most heavy metals because it is primarily non-reactive; that is, it is a noble metal. It's oxidative state is different from aluminum, as is its electrochemistry. Silver, for various and complex reasons, has specific activity against pathogenic organisms.

        "However, in the case of colloidal silver, with no reliable evidence of a benefit and lots of potential risk, it's best to leave the silver for your jewelry!"

        Okay, you are clearly just misinformed or lying. "No reliable evidence of benefit". Are you out of your mind? What did I just post? IT SHOWED INHIBITION OF HIV-1 REPLICATION.

        What about the hundreds and hundreds of other medical studies showing inhibition of pathogenic organisms by the use of nanoparticle silver? With minimal side effects on humans? What do you think was used before the discovery of the lucrative and patentable sulfa antibiotics?

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      • Re: Interaction of silver nanoparticles with HIV-1 by  LuellaMay  5 year  2,615
        I, too, am sickened by mainstream posters with their agendas. 

        You could not be more wrong with regard to colloidal silver and if you did any kind of research other than that found in the fear mongering mainstream websites, you might come up with the true benefits and healing qualities of colloidal silver. 

        And you are so right.  This is a Colloidal Silver Support Forum so we in no way need your false and misleading mainstream input.  You say you want to create balance?  You are in no way creating "balance" using scare tacticts with references from the Mayo Clinic and FDA.  Oh, what a surprise. 

        Although nothing is a "magic bullet" I will say that colloidal silver comes mighty close.  It is effective against many conditions, enhances the immune system and makes any type of infections a thing of the past.  Someone taking colloidal silver even as a preventative experiences nothing less than a stronger immune system, more energy, and overall wellbeing.  They will notice that any type of infections are a thing of the past. 

        What are the alternatives to colloidal silver?  Prescriiption medicines?  Antibiotics?  Medicines that don't work, that cause side effects, and to which pathogens are becoming resistant to?  Colloidal silver was used as a natural antibiotic until modern medicine came into being.  Let's not forget that by taking colloidal silver you can achieve optimum health for pennies a day thereby not supporting Big Pharma and your local physician. 

        What you have posted is nothing but a continuation of the attack waged by mainstream medicine on supplements that truly heal.

        Regards,
        Luella

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      • The only danger of colloidal silver is to Big Pharma drug profits by  dquixote1217  5 year  2,772

        There is NO damaging side to properly made colloidal silver.  NONE!  And, despite all the mainstream propaganda and disclaimers, there is no documented evidence of such damage.  Even the improperly made, large particle contaminated silver that famous Blue Man Papa Smurff Karason took in huge quantities for years, did no damage except for his blue skin condition (which is actually reversible).  In fact, what virtually none of the mainstream media shows will tell you is that Karason was invited by one show to take a physical, which he did - and the results gave him a clean bill of health.

        The only danger colloidal silver represents is to the billions of dollars in profits to the less effective, truly dangerous and highly expensive antibiotics of Big Pharma.

        Colloidal Silver Has Mainstream Medicine Singing the Blues

        DQ

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      • Talk about Mayo Clinic... by  gunnerrat  5 year  3,511
        Several years ago I went to Mayo as part of my job (I wasn't sick, at least when I arrived there I wasn't...)

        I was doing computer work for 2 days and was well away from patients. When I left I had a nasty infection that went straight to my lungs that took over a week to clear out using lemon essential oil (hadn't heard of CS at that time). When I mentioned it later to the people that worked at Mayo they weren't surprised - bad bugs circulate at hospitals like Mayo all the time. The disinfectants they use create nastier bugs. People have actually died of these nasty infections they acquired at the hospital - not of what they came there to get treatment for in the first place. And these are the places you go to get well!

        So you'll excuse me if I'm skeptical, even of big names like Mayo (and I know a thing or two on how they run things there...). Don't be so enamored of impressive-sounding names.

        Check out CS before you put it down. It actually saved my wife a trip to the hospital recently. That alone more than paid for the Silver Puppy I bought. I'm totally sold on it. Anything that keeps me and my family out of the hospital is a good thing.

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        • Re: Talk about Mayo Clinic... by  dquixote1217  5 year  2,583

          The Mayo clinic is infamous for it's staunch support of mainstream medicine and it's suppression of any competition.  That is the clinic that covered up it's own studies on Laetrile (B17) and then fired Doctor Ralph Moss when he revealed the truth.  It is also the clinic whose head of oncology made the incredible statement that "no one has ever been cured of cancer by alternative medicine".  They clearly know who butters their bread and they have zero credibility with me.

          DQ

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      • Re: Interaction of silver nanoparticles with HIV-1 by  above-the-rest  5 year  2,650
        Africana:

        It's easy to determine if someone has taken toxic amounts of silver IF they develop blue or gray tones in the skin after being exposed to the sun. You're right. It is a toxic mineral.

        above-the-rest

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        • Re: Interaction of silver nanoparticles with HIV-1 by  dquixote1217  5 year  2,642

          That must be why NASA uses it to purify the astronauts drinking water.

          If silver were so toxic, why are there no documented reports of harm from colloidal silver?  The blue skin condition known as Argyria is extremely rare, and is not harmful other than the appearance (and it is reversible, contrary to mainstream propaganda).  Even the blue man Papa Smurf Karason was given a physical recently and got a clean bill of health from the massive amounts of contaminated homemade ionic silver he took and added salt to.

          The facts are that the government has tested silver and found no toxicity.  The report has been posted here in this forum if you care to look for it.   Furthermore, there are millions of people who have taken colloidal/ionic silver.  If the blue condition were such a threat, there should be whole tribes of Smurffs running around.

          DQ

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      • there we go again by  gunnerrat  5 year  2,596
        african, you've posted the same stuff earlier, and here you are yet you disturb the same bees nest with the same regurgitation. OK, you don't like CS, then DON'T USE IT! We know your opinion, we disagree, so we'll agree to disagree. I don't know what you're up to, but it's pointless. I'm sure there's some corner of CZ that agrees with you, so go there.

        We disagree. So what's the point?

        Oh, and by the way, the problem with Blue Man is he's blue! He's not suffering from failed kidneys. He feels better than ever, so spout your nonsense to him instead.

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      • Re: Interaction of silver nanoparticles with HIV-1 by  SpeakerofTruth  5 year  2,557
        Take your Big-Pharma funded self-serving arse elsewhere... it sure as hell aint wanted here. In regards to the FDA, if you arent cluelessly living in the caveman age... then you know that the only thing they serve is their profit-masters and not the public in at large and by and large they are one of the most corrupt and hopelessly outdated and inefficent organizations in the government who really just do their masters bidding and any semblence of their original intentions (which is to serve and protect the people) has long since been extinguished. A good rule of thumb is if something works and works exceptionally well, then modern medicine/FDA/Big Pharma will do its best to discredit "it" whatever that maybe by any means necessary.

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    • 'important points' by  happyhealthygal  5 year  2,730
      I mentioned and linked this article on an answer to a question about CS for HIV a while ago - I suppose it was foolishly optimistic to think that anyone might have followed the link and read it!
      ...

      Sorry, we had to truncate this message! ... Click here to read it

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      • Re: 'important points' by  Exploited Citizen  5 year  2,595
        Some of those studies quoted were for Silver Nitrate, which was broadly used many years ago to prevent infections in new babies eyes.

        If you've ever read the Body Electric by Dr. Robert O Becker he paints a much different story of silver.

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        • Re: 'important points' by  happyhealthygal  5 year  2,547
          All of the toxicity studies related to silver nanoparticles (pure silver).

          Some (not all) of the articles on silver-resistant bacteria were indeed testing against AgNO3 (silver nitrate).
          However, do you have any reason to believe that the organisms resistant to AgNO3 are not also resistant to Ag+? They've identified at least some of the plasmids encoding silver resistance (which confers resistance to AgNO3):
          http://www.springerlink.com/content/k7q3077u3365l706/

          The reason they were testing against AgNO3 is because that is the silver compound most frequently used.

          My point was not to say that if someone uses silver, they will necessarily become resistant to it; I was merely pointing out that those who say it's impossible or won't happen don't appear to be supported. If everyone is using silver chronically, whether they have a need to use it or not, silver resistance is a very real possibility, although in some cases the fitness cost may prevent it from being widespread (although this is a bit of an unknown).
          Resistance to nanoparticles may be a different issue.

          Nope, never read the book. I don't much read popular press containing new theories of human physiology or disease - they tend to be high on claims and low on science. My assumption is that if someone is doing important work, they'll publish it in a reputable scientific journal.

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          • Re: 'important points' -EDIT by  happyhealthygal  5 year  2,542
            All of the toxicity studies related to silver nanoparticles (pure silver).

            Some (not all) of the articles on silver-resistant bacteria were indeed testing against AgNO3 (silver nitrate).
            However, do you have any reason to believe that the organisms resistant to AgNO3 are not also resistant to Ag+? They've identified at least some of the plasmids encoding silver resistance (which confers resistance to AgNO3):

            http://www.springerlink.com/content/k7q3077u3365l706/


            The reason they were testing against AgNO3 is because that is the silver compound most frequently used.

            My point was not to say that if someone uses silver, they will necessarily become resistant to it; I was merely pointing out that those who say it's impossible or won't happen don't appear to be supported. If everyone is using silver chronically, whether they have a need to use it or not, silver resistance is a very real possibility, although in some cases the fitness cost may prevent it from being widespread (although this is a bit of an unknown).
            Resistance to nanoparticles may be a different issue.

            Nope, never read the book. I don't much read popular press containing new theories of human physiology or disease - they tend to be high on claims and low on science. My assumption is that if someone with scientific credentials is doing important work, they'll publish it in a reputable scientific journal so that their claims can be evaluated by other scientists rather than a by an often-uninformed lay public.

            EDIT: I didn't mean the previous statement to sound snobbish. I meant that when a scientist makes what he believes is an important finding or has a theory he believes to be correct, he'll want others to test it, validate his findings, etc, and write responses that perhaps point out the weaknesses in his argument. None of this is likely to happen when he's publishing in the popular press rather than scientific journals.

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          • Re: 'important points' by  ino  5 year  2,554
            If I may add to the previous post here regarding Dr.Robert O Becker, don't confuse him with Dr Robert Beck, however both these gentlemen were highly qualified and respected in their respective fields of science. Could I recommend you do a little research on Dr Robert O Becker because you will find that his book, "The Body Electric", details some incredible information. He never published in 'popular' press so to speak, as far as I know, (but of course I don't know everything about the man, but I have read some of his work). His enlightening work and experiments could not proceed due to further funding being refused or withdrawn. On reading some of his work I believe you will get a better understanding of why he perhaps is not as well known and read as some, and one can speculate possibly, why further funding was not forthcoming. I'm serious here, his research work really was groundbreaking and deserves to be better read and recognised. His name can sit at the same level as Einstein and Freud but in a different field of science. He pushed the 'accepted' boundaries regarding pharmaceuticals and paid the price, [my opinion], as did Dr Robert Beck, (he deserves more reading as well).

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      • Yes, size matters by  dquixote1217  5 year  2,604

        At least it does insofar as silver is concerned.  In other areas, it is not as important - or at least that is information I have been getting away with for lo these many years.

        I might point out that the silver made by Utopia Silver has a mean average of 2 nanometers and a range of .64 nanometers to 9 nanometers - precisely within the range shown to be effective in Sunver's post.

        Some other points:

        • One would presume that if the particles can get in, they can also get out unless our body's and cells are a system of one-way doors.
        • As another poster pointed out, some of what you referenced regarded silver nitrate, a different animal than colloidal/ionic silver.
        • Surface area matters far more than quantity, though certainly quantity does matter.
        • Insofar as dangers, thus far there has not been one single instance of danger from properly made colloidal or ionic silver despite no end of mainstream propaganda to the contrary.  Even the famous blue man, Papa Smurff Karason, was found to have a clean bill of health - and he has consumed massive amounts of improperly made and contaminated silver for years.

        DQ

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