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Aspirin Misuse May Have Made 1918 Flu Pandemic Worse

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  • Image Embedded Aspirin Misuse May Have Made 1918 Flu Pandemic Worse by  LCD  4 year  3,343  News / Flu / Swine Flu / 4 / 5 / 6
    Aspirin Misuse May Have Made 1918 Flu Pandemic Worse

    ScienceDaily (Oct. 3, 2009) —


    The devastation of the 1918-1919 influenza pandemic is well known, but a new article suggests a surprising factor in the high death toll: the misuse of aspirin. Appearing in the November 1 issue of Clinical Infectious Diseases and available online now, the article sounds a cautionary note as present day concerns about the novel H1N1 virus run high.


    http://www.sciencedaily.com/releases/2009/10/091002132346.htm


    High aspirin dosing levels used to treat patients during the 1918-1919 pandemic are now known to cause, in some cases, toxicity and a dangerous build up of fluid in the lungs, which may have contributed to the incidence and severity of symptoms, bacterial infections, and mortality. Additionally, autopsy reports from 1918 are consistent with what we know today about the dangers of aspirin toxicity, as well as the expected viral causes of death.

    The motivation behind the improper use of aspirin is a cautionary tale, said author Karen Starko, MD. In 1918, physicians did not fully understand either the dosing or pharmacology of aspirin, yet they were willing to recommend it. Its use was promoted by the drug industry, endorsed by doctors wanting to “do something,” and accepted by families and institutions desperate for hope.

    “Understanding these natural forces is important when considering choices in the future,” Dr. Starko said. “Interventions cut both ways. Medicines can save and improve our lives. Yet we must be ever mindful of the importance of dose, of balancing benefits and risks, and of the limitations of our studies.”





    Journal reference:

    1.Karen M. Starko. Salicylates and Pandemic Influenza Mortality, 1918%u20131919 Pharmacology, Pathology, and Historic Evidence. Clinical Infectious Diseases, 2009; DOI: 10.1086/606060
    Adapted from materials provided by Infectious Diseases Society of America.


    http://www.sciencedaily.com/releases/2009/10/091002132346.htm



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    • Re: Aspirin Misuse May Have Made 1918 Flu Pandemic Worse  RR by  trapper/kcmo  4 year  3,317
      i laugh when i hear people talk about the past like we know so much better now. since when have we learned from our mistakes? the thought makes me cringe.

      it might also be a fact that using aspirin as a fever reducer allowed the 1918 virus to escape a major biological defense that greatly curbs viral replication and speeds other immune responses. basically, if the temp is going up, one should aid this effort initially by piling on covers or submersing in a hot bath. dangerous temps can be dealt with if and when they are approached. there are so many diminished metabolisms out there that achieving a fever can be somewhat of a feat in itself. viruses dont like over 101. when you start out at 97.?? then you are behind the curve already and have lost much of your ability to fend off being overcome by the flu.

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      • Re: Aspirin Misuse May Have Made 1918 Flu Pandemic Worse by  UserX  4 year  2,984
        Yes, when I was little and got sick, my mom always piled the blankets on me and my 2 sisters. I always felt very "taken care of" we got soup, or coke and peppermint sticks if we were nauseous. The blankets would usually make the fever "break" later and we would start sweating. Then begin to feel better. We all did fine without aspirin.

        Unfortunately, I listened to my pediatrician and gave Tylenol when my son had fevers. The fear was that high fevers caused seizures. And they do, but I guess you do have to keep takinjg the temp and make sure it isn't getting above 104 or so (for a child).

        We all caught both kinds of measles, chicken pocks, one sister got mumps, I don't remember getting them, but maybe I had antibodies from when she did and I just didn't show it. I was looking at a current vaccination schedule and it is scary. Unreal all the stuff they are putting in babies and toddlers. All I remember getting was a smallpox shot, a polio sugar cube, maybe there was 1 more but I don't recall. I was born in 1957. My 28 year old son even got way fewer than they do now.

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        • Re: Aspirin Misuse May Have Made 1918 Flu Pandemic Worse by  uchihaMadara  4 year  3,008
          The vaccination schedule is increasing in frequency. Paranoid mothers think they are doing the best thing when they opt-in. The worst a mother can do is choose multiple vaccination shots at the same time for a kid.

          Where I work (a hospital), if a patient has a fever, they almost always prescribe tylenol (ASA) to reduce fever. Oh, and they are proud users of "evidence-based practice!"

          I do recall always just going through a flu or cold, under a warm blanket, and feeling better after a few days of eating easy on the stomach foods like soup. The heat is necessary to stop virus action, activate t-cells, and increase circulation of t-cells. Higher temperature equates to more energy in the body working to cure a dis-ease.

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      • Re: Aspirin Misuse May Have Made 1918 Flu Pandemic Worse by  Freedom Citizen  4 year  3,005
        Morever you've lost any naturally acquired immunity or resilience when a contrived substance suppressively intervenes.

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    • Re: Aspirin Misuse - The Two Sides of The Coin by  Will_I_Ever_Learn  4 year  4,494

      The Two Sides of The Coins
       
      Against Aspirin
      --Beginning of quote--
      The high case-fatality rate—especially among young adults—during the 1918–1919 influenza pandemic is incompletely understood. Although late deaths showed bacterial pneumonia, early deaths exhibited extremely “wet,” sometimes hemorrhagic lungs. The hypothesis presented herein is that aspirin contributed to the incidence and severity of viral pathology, bacterial infection, and death, because physicians of the day were unaware that the regimens (8.0–31.2 g per day) produce levels associated with hyperventilation and pulmonary edema in 33% and 3% of recipients, respectively. Recently, pulmonary edema was found at autopsy in 46% of 26 salicylate‐intoxicated adults. Experimentally, salicylates increase lung fluid and protein levels and impair mucociliary clearance. In 1918, the US Surgeon General, the US Navy, and the Journal of the American Medical Association recommended use of aspirin just before the October death spike. If these recommendations were followed, and if pulmonary edema occurred in 3% of persons, a significant proportion of the deaths may be attributable to aspirin.
      --end of quote--
       
       
      But Many Swine Flu Cases Have No Fever
       
       
      Pro Aspirin
       
      Swine Flu Cytokine Storm Cures
      Turmeric, Fish Oil and Aspirin Provide Anti-Inflammatory Protection
      --Beginning of quote--
      Swine Flu Cytokine Storm Cures
      Turmeric, Fish Oil and Aspirin Provide Anti-Inflammatory Protection
       
      The swine flu epidemic centered in Mexico City appears to be a modern replay of the Spanish influenza epidemic of 1918-19. Infants and elderly were spared. It was the young adults with robust immune systems that were the prime victims and the disease took them literally by storm.
       
      Cytokine Storm -- Immune System out of Control
       
      The Spanish flu killed by producing a virulent immune response with production of large amounts of the immune system hormones, the inflammatory cytokines IL-1, IL-6 and TNF. These are the cytokines associated with the symptoms of infection, fever, fluid retention/swelling, malaise, headache, etc. These are the inflammatory symptoms that normally transition into recovery, but in the case of swine flu, additional cytokines are produced, including anti-inflammatory IL-10. The problem appears to be that the sudden IL-10 signaling disrupts the natural transition from inflammation to recovery and the inflammatory signaling becomes acute and life-threatening.
       
      Acute Inflammation Kills by Fluid in Lungs
       
      The swine flu epidemics in Spain and once again in Mexico kill by immunological inflammation that causes fluid to accumulate in lungs, i.e. acute respiratory distress syndrome (ARDS) triggered by a cytokine storm.
       
      This type of organ failure is similar to the consequences of systemic infection, septicemia. These severe infections initiate an acute inflammatory response that may be very dangerous, but in many ways their similarity to swine flu symptoms may be fortuitous. Treatment for cytokine mediated multiple organ failure may provide some possible approaches to the treatment of swine flu, which avoid evolution of H1N1 caused by antiviral drugs such as Tamiflu.
       
      Anti-inflammatory Treatment for Swine Flu
       
      Cytokine storms associated with sepsis and ARDS have been treated by forcing progression of the inflammatory process into its recovery phase. Some of the most effective approaches use recognizable anti-inflammatory compounds: aspirin, omega-3 fatty acids (fish oil) and curcumin (turmeric).
       
      Aspirin may block cytokine storms by altering COX-2 to produce anti-inflammatory eicosanoids and lipoxins. Aspirin also blocks the major inflammatory transcription factor, NFkB. Of course, the administration of aspirin to children with viral diseases, is counter-indicated, because of the risk of Reye syndrome. The omega-3 fatty acid EPA is converted by COX-2 into an anti-inflammatory prostaglandin. Curcumin is one of the most potent inhibitors of NFkB. This trio of anti-inflammatory natural compounds may ultimately be major players in blocking the killing capacity of swine flu.
      --end of quote--
       
       
       
      --Beginning of quote--
      10/04/2009: Ted from Bangkok, Thailand replies: "The truth is the popularity in aspirin was the very fact that 1918 Spanish flu viruse STOPPED the epidemic. It didn't just stopped by itself. I learned this only AFTER I have found that independently that aspirin did kill the bird flu, swine flu and dengue fever. I have as yet looking over the possibility of use in Hanta viruses, but that I don't know. What the aspirin does is it just digest the viruses when I look over a very high powered electron microscope during my student days even in very weak solutions. May I also remind you that I have seen (I can't say I cured for legal reason) that I have this person with a two year Chlamydia, which resists ALL KINDS of antibiotics (you name it, azithromycin, terramycine, amoxcillin, etc) and I finally gave up and aspirin was tried. The dose was 500 mg of aspirin, taken hourly for four tablets, each tablets is DISSOLVED in a cup of warm water. It was completely gone. The uniqueness of the aspirin is the salicyclic acid portion that dissolves any bacteria and many viruses sight. The chlamydia NEVER came back! Imagine a man with chlamydia eating up his testicles and you can imagine the pain he's suffering with the Chlamydia.
       
      People who goes to talk shows are likely have vested financial interests, I DON'T go to any talk shows and rather tell the truth under the radar or scrutiny of the pharma industry and I think this is the best approach for me. For the unbelievers, I have plenty of people here who can vouch that the aspirin did work and it's synergistic with the vitamin C. It wasn't easy finding the cure, but once it's found I hope people will find some benefit, especially the fact that vaccinations are dangerous with highly dangerous bacteria and viruses, and they are live bacteria and viruses. Hence, to neutralize these, I only expect at least just taking ASPIRIN (or lysine) hourly for only 4 times in one day. It's the bare minimum so that the vaccination should it be mandatory there is A WAY AROUND this problem. The use of digestive enzyme works too, but it is not nearly as dramatic as lysine or aspirin. Perhaps I have to look into this further with dose/frequency issue.
       
      Thank you for your support!
       
      Ted"
      --end of quote--
       
      --Beginning of quote--
      In Thailand, we currently have an epidemic running, which is mostly Swine flu (2009 virus), Dengue Fever, and Chikungunya. While it is somewhat of an epidemic, the currently "mainstream" media recognized is the Swine flu 2009 virus or the same Bird flu. It's still H1N1 regardless of the name and to subdue the virus scare, by naming new names to the H1N1. One of the MAJOR problems concerning its cure and my remedies is that Lysine isn't available in Thailand, or is difficult to obtain. BHT is impossible to get for most people. Therefore I have to devise a very simple cure (yes a real cure) using a simple aspirin from and perhaps some vitamin C, if you can get it. Now Thailand in some remote villages vitamin C are harder to get then getting an aspirin.
       
      The idea of using aspirin as a cure for pneumonia, and all kinds of flu, is nothing new. During my studies in microbiology during my college year stint in the U.S., I have noticed that a serial dilution of aspirin virtually dissolves any virus in sight. Fellow students who got lazy sometimes throw aspirin tablets in a shrimp egg hatching facility to kill the shrimp viruses as well. The chemical of aspirin is acetylsalicylic acid. When I say it kills any viruses, this applies for metastatic cancer, which is a viral form of cancer virus. It works the same way using the aspirin too and you can see results in less than 6 hours, using the hourly dose of taken for 4 or 5 times of aspirin.
       
      The acetyl portion makes the salicylic acid "water soluble" as well as it's unique properties in digesting viral or bacterial coating, especially the viral coating (alkaline potassium compound being the other one), that it can come into contact with.
       
      In fact there's an almost 100% kill, more closer to about 99% kill rate when a very weak solutions of aspirin is in contact with any viral coating, and aspirin replenished for the next 3 or 4 hours as it is "used up".
       
      It's the acetyl portion plus the salicylic acid which makes it deadly. It digest these viral proteins thousand times more quicker than it does damage to the healthy cells. Obviously, the aspirin was working better than any antiviral medicines known, so my colleagues mentioned that "they" were going to stop that dreaded practice. (It hurts research funding on novel very expensive but ineffective antiviral medications LOL). Remember at the time of my studies, that was in the late 1970s., so obviously (2009) aspirin is now almost universally condemned.
       
      Because of this, I have to make another trials last month to prove that aspirin does work. It SHOULD be noted that aspirin is effective even if it is taken ALONE. But if you want it to be more effective, a vitamin C sodium ascorbate can be taken on INITIAL dose, being the bare minimum such as 500 mg. This causes the white blood cells to uptake the vitamin C more than it's usual capacity allowing for the body's immune system to go much higher than normal. In any case the simplest of all cure of any flu that I know of regardless of what kind of flu you have is the following remedy:
       
      For adult dose 500 mg of aspirin taken LESS than 1 hour apart, preferably, 50 minutes but not exceeding 1 hour. The dose is taken for no more than 4 times, with maximum of 5 times. I haven't quite work about the optimal frequency between dose to keep active acetylsalicylic acid blood concentration stable so that it's antiviral capabilities at a maximum.
      --end of quote--
       
      Maybe timing and dosages make all the differences.
       
      WIEL

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