CFS can sometimes be a bit more complictated than just the viral load. But the viral load can play a big part.
Adrenal fatigue is often the cause of a low immune sytem. Although this is not always the case. That is why I would suggest if someone is not sure if they have AF to check their temperatures.
Being in a low metabolic state will often compromise the immune system by allowing in viruses. This in turn lets in heavy metals, bacteria, funguses ect. Viruses and heavy metals love to live together :) Its a vicious circle. This in turn makes the adrenals weaker and more difficult to heal no matter how many supplements you throw at it.
In the end you land up in a position where you can't detox the heavy metals because your adrenals are too weak. The supplemsenst are not working because of the viruses, heavy metals, funguses. A right mess :)
Dr Amy Yasko who does a lot of work with Autistic children picked this up ages ago.( The viruses and heavy metals)
So I started using transdermal Iodine again, I take 4 drops of Lugol's solution per day. That gives me roughly 1mg iodine per day. This really has helped my crash tolerance a ton. However, it gives me brain fog. Weird huh?
Normal iodine supplementation is using iodoral, which yields 12.5mg iodine, I reckon if I took an iodoral I would be 1)thrust into a panic attack OR 2)in a severe state of brain fog.
Transdermal iodine (about 6% estimated absorption rate) does effect me quite a bit .....
I have never looked into iodine. I think a better option might be selenium for you.I think it does the same thing but more. I am going to make a post on it soon. Everybody should be taking it.
Makes gluthathione. Deactives viruses. Detoxifies heavy metals. Detoxifies the liver. Boosts the thyroid. I am going to go 4 times(800ug) the RDA(200ug) for 4 weeks starting tomorrow. At 5 times it becomes toxic. To get my levels up then settle on 400 ug daily.
I don't know, what I do know is that I am currently exploring the mold hypothesis the most. I know a lot about vitamins/diet/drugs, but I also know that I felt my best in hawaii, more than anything that drugs/diet/vitamins can help.
A lot of people report similar findings, that dry clean climates help the most. I am going to visit the desert in california soon to see how that helps. I have weird stuff like prostatitis and fibromyalgia pains that completely disappear when I go to a dry climate, I also feel more energy.
I think Adrenal Fatigue is just simply the body lowering production of adrenal hormones like cortisol in order to save the immune system. Adrenal hormones are immunosuppressants, so they suppress the immune system. I think we get an infection, and then our bodies decide to lower adrenal hormones to save our body from the infection.
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Low immune system from AF? 
