More good news on turmeric/Curcumin and the healing found in our Kitchen Cabinets. There are several herbs that should be a weekly, if not daily part of our food preparation and turmeric is definitely high on the list. Here we see research on it's preventative effect with infections - http://www.sciencedaily.com/releases/2012/05/120525103915.htm
Oregon State University scientists just identified a new reason why some curry dishes, made with spices humans have used for thousands of years, might be good for you.
New research has discovered that curcumin, a compound found in the cooking spice turmeric, can cause a modest but measurable increase in levels of a protein that's known to be important in the "innate" immune system, helping to prevent infection in humans and other animals.
This cathelicidin antimicrobial peptide, or CAMP, is part of what helps our immune system fight off various bacteria, viruses or fungi even though they hadn't been encountered before. Prior to this, it was known that CAMP levels were increased by vitamin D.
Turmeric is a flavorful, orange-yellow spice and an important ingredient in many curries, commonly found in Indian, South Asian and Middle Eastern cuisine. It has also been used for 2,500 years as a medicinal compound in the Ayurvedic system of medicine in India -- not to mention being part of some religious and wedding ceremonies. In India, turmeric is treated with reverence.
The newest findings were made by researchers in the Linus Pauling Institute at OSU and published in the Journal of Nutritional Biochemistry, in collaboration with scientists from the University of Copenhagen in Denmark. The work was supported by the National Institutes of Health.
"This research points to a new avenue for regulating CAMP gene expression," said Adrian Gombart, an associate professor of biochemistry and biophysics in the Linus Pauling Institute. "It's interesting and somewhat surprising that curcumin can do that, and could provide another tool to develop medical therapies."
The impact of curcumin in this role is not nearly as potent as that of vitamin D, Gombart said, but could nonetheless have physiologic value. Curcumin has also been studied for its anti-inflammatory and antioxidant properties.
"Curcumin, as part of turmeric, is generally consumed in the diet at fairly low levels," Gombart said. "However, it's possible that sustained consumption over time may be healthy and help protect against infection, especially in the stomach and intestinal tract."
In this study, Chunxiao Guo, a graduate student, and Gombart looked at the potential of both curcumin and omega-3 fatty acids to increase expression of the CAMP gene. They found no particular value with the omega-3 fatty acids for this purpose, but curcumin did have a clear effect. It caused levels of CAMP to almost triple.
There has been intense scientific interest in the vitamin D receptor in recent years because of potential therapeutic benefits in treating infection, cancer, psoriasis and other diseases, the researchers noted in their report. An alternative way to elicit a related biological response could be significant and merits additional research, they said.
The CAMP peptide is the only known antimicrobial peptide of its type in humans, researchers said. It appears to have the ability to kill a broad range of bacteria, including those that cause tuberculosis and protect against the development of sepsis.
As more research shows the connection between inflammation and many diseases—from cancer to cognitive decline—it’s increasingly important that researchers continue to explore ingredients that promote a healthy inflammatory response.
A recent human clinical trial published in the March 2012 edition of Phytotherapy Research, demonstrated that BCM-95, a highly bioavailable form of curcumin, was as effective in alleviating symptoms of rheumatoid arthritis (RA) as diclofenac sodium (branded Voltaren, a leading pharmaceutical NSAID treatment).
The single-blinded pilot study was designed to determine whether twice daily supplementation with 500mg capsule of curcumin separately and in combination with diclofenac sodium (50mg) for eight weeks would improve Disease Activity Scores in patients diagnosed with active RA.
Forty-five participants were randomized to three groups (curcumin only, curcumin in combination with diclofenac sodium and diclofenac sodium only) and after eight weeks of therapy their DAS scores were reassessed along with the American College of Rheumatology (ACR) criteria for reduction in tenderness and swelling of joints.
The BCM-95 curcumin group experienced the most improvement, though the score change wasn’t sufficiently higher than the combination and drug-only scores to call it an out-and-out winner, explained Cheryl Myers, chief of scientific affairs and education at EuroPharma, makers of CuraMed which uses BCM-95 to promote a healthy inflammation response.
Nonetheless, “the findings of this study are significant, as these demonstrate that curcumin was not only safe and effective, but was surprisingly more effective in alleviating pain compared with diclofenac,” wrote the study authors Binu Chandran and Ajay Goel.
Victory for curcumin
What we can deem an out-and-out victory, however, is that in the BCM-95 curcumin group there were no drop outs due to adverse effects, but in the diclofenac sodium (NSAID) group, 14 percent withdrew due to adverse effects.
According to Myers, as many as 20,000 Americans die each year from the negative effects of NSAIDs—ulcers, stomach bleeding, kidney function disruption and intestinal bleeding, to name a few. The indication that BCM-95 curcumin might offer a safer and equally as effective alternative to drug treatment should not only offer hope to RA sufferers, but inspire further research on this important ingredient.
“Our observations that curcumin alone was able to alleviate symptoms of rheumatoid arthritis in this study are quite encouraging, and these results provide an ideal springboard for investigating the potential of curcumin in other chronic diseases arising in the setting of dysregulated chronic inflammation,” wrote Chandran and Goel.
UCLA researchers discovered that a diet enriched with a popular omega-3 fatty acid and an ingredient in curry spice preserved walking ability in rats with spinal-cord injury. Published June 26 in the Journal of Neurosurgery: Spine, the findings suggest that these dietary supplements help repair nerve cells and maintain neurological function after degenerative damage to the neck.
"Normal aging often narrows the spinal canal, putting pressure on the spinal cord and injuring tissue," explained principal investigator Dr. Langston Holly, associate professor of neurosurgery at the David Geffen School of Medicine at UCLA. "While surgery can relieve the pressure and prevent further injury, it can't repair damage to the cells and nerve fibers. We wanted to explore whether dietary supplementation could help the spinal cord heal itself."
The UCLA team studied two groups of rats with a condition that simulated cervical myelopathy -- a progressive disorder that often occurs in people with spine-weakening conditions like rheumatoid arthritis and osteoporosis. Cervical myelopathy can lead to disabling neurological symptoms, such as difficulty walking, neck and arm pain, hand numbness and weakness of the limbs. It's the most common cause of spine-related walking problems in people over 55.
The first group of animals was fed rat chow that replicated a Western diet high in saturated fats and sugar. The second group consumed a standard diet supplemented with docosahexaenoic acid, or DHA, and curcumin, a compound in turmeric, an Indian curry spice. A third set of rats received a standard rat diet and served as a control group.
Why these supplements? DHA is an omega-3 fatty acid shown to repair damage to cell membranes. Curcumin is a strong antioxidant that previous studies have linked to tissue repair. Both reduce inflammation.
"The brain and spinal cord work together, and years of research demonstrate that supplements like DHA and curcumin can positively influence the brain," said coauthor Fernando Gomez-Pinilla, professor of neurosurgery. "We suspected that what works in the brain may also work in the spinal cord. When we were unable to find good data to support our hypothesis, we decided to study it ourselves."
The researchers recorded a baseline of the rats walking and re-examined the animals' gait on a weekly basis. As early as three weeks, the rats eating the Western diet demonstrated measurable walking problems that worsened as the study progressed. Rats fed a diet enriched with DHA and curcumin walked significantly better than the first group even six weeks after the study's start.
Next, the scientists examined the rats' spinal cords to evaluate how diet affected their injury on a molecular level. The researchers measured levels of three markers respectively linked to cell-membrane damage, neural repair and cellular communication.
The rats that ate the Western diet showed higher levels of the marker linked to cell-membrane damage. In contrast, the DHA and curcumin appeared to offset the injury's effect in the second group, which displayed equivalent marker levels to the control group.
Levels of the markers linked to neural repair and cellular communication were significantly lower in the rats raised on the Western diet. Again, levels in the animals fed the supplemented diet appeared similar to those of the control group.
"DHA and curcumin appear to invoke several molecular mechanisms that preserved neurological function in the rats," said Gomez-Pinilla. "This is an exciting first step toward understanding the role that diet plays in protecting the body from degenerative disease."
"Our findings suggest that diet can help minimize disease-related changes and repair damage to the spinal cord," said Holly. "We next want to look at other mechanisms involved in the cascade of events leading up to chronic spinal-cord injury. Our goal is to identify which stages will respond best to medical intervention and identify effective steps for slowing the disease process."
It's great... but I worry about it's antibiotic properties.
For candida it was used to clean out someone's colon (article should findable with a google search). Likely of everything good and bad. But I wonder if it's as effective systemically. or if it's better added to sauerkraut. No time to find out.
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