CureZone
Old Format -> CureZone.INFO
Re: Does taking fish oil make you "smelly"? (Please help)
Forum: Ask CureZone Community
 
  • Does taking fish oil make you "smelly"? (Plea...   ilove80s   5y  C
    • Try a different brand of fish oil or maybe sw...   LuellaMay   5y
    • Hi ilove80s, ... ... If you have a deficienc...   white tiger   5y
      • Thanks for the information. Because of my es...   ilove80s   5y
        • http://en.wikipedia.org/wiki/Trimethylaminuri...   white tiger   5y
          This is NOT my avatar. This is just randomly assigned image, until I upload my own avatar. Click here to see my profile.
          white tiger
          Re: Does taking fish oil make you "smelly"? (Please help)
          PM
          Date: 3/29/2009 3:54:07 AM   ( 5y ago )
          Hits:   22583   Size: 5053 char.   Bad Message Alert: Alert Moderators on This BAD Message   Good Message Alert: Alert Moderators on This GOOD Message
          http://en.wikipedia.org/wiki/Trimethylaminuria


          Trimethylamine builds up in the body of patients with trimethylaminuria. The trimethylamine gets released in the person's sweat, urine, reproductive fluids, and breath, giving off a strong fishy odor. Some people with trimethylaminuria have a strong odor all the time, but most have a moderate smell that varies in intensity over time. Individuals with this condition do not have any physical symptoms, and typically appear healthy.[5]

          The condition seems to be more common in women than men, for unknown reasons. Scientists suspect that female sex hormones, such as progesterone and/or estrogen, aggravate symptoms. There are several reports that the condition worsens around puberty. In women, symptoms can worsen just before and during menstrual periods, after taking oral contraceptives, and around menopause.[5]

          This odor varies depending on many known factors, including diet, hormonal changes, other odors in the space, and individual sense of smell.
          -------------------------------

          Diagnosis
          Measurement of urine for the ratio of trimethylamine to trimethylamine oxide is the standard screening test. A blood test is available to provide genetic analysis. The prominent enzyme responsible for TMA N-oxygenation is coded by the FMO3 gene.

          A similar test can be used to identify carriers of this condition - those individuals who carry one copy of a mutated gene but do not have symptoms. In this case, the person would be given a high dose of choline (one of the precursors of trimethylamine) and then have their urine tested for elevated levels of trimethylamine.


          [edit] Treatment
          Currently, there is no cure and treatment options are limited. However, it is possible for some people with this condition to live relatively normal, healthy lives without the fear of being shunned because of their unpleasant odor. Getting tested is an important first step. Ways of reducing the odor include:

          Avoiding foods such as eggs, legumes, certain meats, fish, and foods that contain choline, carnitine, nitrogen, and sulfur
          Taking low doses of antibiotics to reduce the amount of bacteria in the gut
          Using slightly acidic detergents with a pH between 5.5 and 6.5
          At least one study[6] has suggested that the daily intake of charcoal and/or copper chlorophyllin may be of significant use in improving the quality of life of individuals suffering mild forms of TMAU. Success rates varied:
          85% of people tested completely lost their "fishy" odor
          10% partially lost their odor
          5% kept the scent
          However, whilst they may be beneficial in some cases, many people in trimethylaminuria support groups who have tried charcoal and copper chlorophyllin have reported disappointing results.

          Also helpful are:

          Behavioral counseling to help with depression and other psychological symptoms
          Genetic counseling to better understand their condition.
          --------------------------------

          Genetics

          Trimethylaminuria has an autosomal recessive pattern of inheritance.Most cases of trimethylaminuria appear to be inherited in an autosomal recessive pattern, which means two copies of the gene in each cell are altered. The parents of an individual with an autosomal recessive disorder are carriers of one copy of the altered gene. Carriers may have mild symptoms of trimethylaminuria or experience temporary episodes of fish-like body odor.

          Mutations in the FMO3 gene, which is found on the long arm of chromosome 1, cause trimethylaminuria. The FMO3 gene makes an enzyme that breaks down nitrogen-containing compounds from the diet, including trimethylamine. These compounds are produced by bacteria in the intestine as they digest proteins from eggs, meat, soy, and other foods. Normally, the FMO3 enzyme converts fishy-smelling trimethylamine into trimethylamine N-oxide which has no odor. If the enzyme is missing or its activity is reduced because of a mutation in the FMO3 gene, trimethylamine is not broken down and instead builds up in the body. As the compound is released in a person's sweat, urine, and breath, it causes the strong odor characteristic of trimethylaminuria. Researchers believe that stress and diet also play a role in triggering symptoms.

          There are more than 40 known mutations associated with TMAU.[7][8] Loss-of-function mutations, nonsense mutations, and missense mutations are three of the most common. Nonsense and missense mutations cause the most severe phenotypes.

          Although FMO3 mutations account for most known cases of trimethylaminuria, some cases are caused by other factors. A fish-like body odor could result from an excess of certain proteins in the diet or from an increase in bacteria in the digestive system. A few cases of the disorder have been identified in adults with liver damage caused by hepatitis.

          The evolution of the FMO3 gene has recently been studied, including the evolution of some mutations associated with TMAU.
          Your reply:
          Reply   CK  FCK  MCE
          Printer-friendly version of this page
          Email this message to a friend
          Bookmark this page/Add to Favorites or press Ctrl+D
          Alert Webmaster & Moderators
          Bad Message Alert: Alert Moderators on This BAD Message  Good Message Alert: Alert Moderators on This GOOD Message
          How do you feel about this message?     Like     Dislike       Hide this question
          Find & Order All Messages Posted by white tiger
          by
          DISCLAIMER




          Medianet Ads




 
Medianet Ads



 

 
Back To Top

Selected Ads from CureZone Sponsors: Become a Sponsor

VIP

14 Liver Cleansing Foods
I would encourage you to incorporate these liver cleanse foods into ...
High Blood Pressure?
3 easy exercises drop blood pressure below 120/80 as soon as today
Homeopathic Arthritis Creme
For fast recovery after sport injuries and for Arthritis pain cli...
 
 

PLAT

Iodine Supports Thyroid Health
#1 Rated Iodine Supplement! 180-Day Money Back Guarantee. Free...
Hulda Clark Cleanses
Free Shipping on order over $29
Free Book by Dr. Clark!
Bestselling author Dr. Hulda Clark claims to have cured cancer. Is sh...
Natural Cancer Remedies
 
 

GOLD

Proven medical anti-diabetic benefits
Electrolyzed drinking water significantly reduces blood...
Proven Candida Diet
The Only Legitimate Diet for Treating Candida in 30 Days
Cancer’s Natural Enemy
Opc Oleander, 15% Discount With Curezone Discount Code Of Lr001
Kill Parasites Naturally
How to Kill Parasites Naturally & Feel Great in 30 Days or Less
 
 

GOLD

Detoxify and Cleanse Naturally
Drink ionized alkaline waters medically proven health benefits...
Natural Immune System Booster
Try Immunophen, which is designed to build and maintain a healt...
 
 

SILVER

Lugol’s Iodine Free S&H
J.Crow’s® Lugol’s Iodine Solution. Restore lost reserves.
Ccws™
Clinically proven effective against Candida, Yeast Infections & thrush
Life Technology™
Transformational Technology For Mind Body And Soul.
Cancer, HIV and Hep-C Remedy
Proven natural remedy for cancer, HIV, Hep-C and much more!
 
 
Back To Top How many people click on the sponsord links? Become a Sponsor

 


 

Donate to CureZone

 


Share:  Facebook  MySpace  Digg  Reddit  StumbleUpon  Furl this page  Delicious  BlinkList  dzone  Simpy.com  Fark.com  BlogMarks  Wists.com  Google

Translate This Page:

French    German    Spain    Italian    Dutch    Russian    Portuguese    Japanese    Korean    Arabic    Chinese Simplified



 


Guest Book - Liver Flush FAQ - News - Link Exchange - Add URL - How To Exchange Links? - About Global Directory

Terms of Service - Privacy Policy - Spam Policy - Disclaimer - Guidelines & Rules - Forum Trolls - Fair use notice

Staff's pages:  Owen - Wrenn - Maya


CureZone Newsletter is distributed in partnership with www.netatlantic.com


Contact Us - About - Donors - Stats



Copyright 2014  curezone.com


fetched in 1.06 sec at 9/19/2014 10:50:29 AM, requested by 54.205.254.108, referred by http://curezone.com/forums/fm.asp?i=1384969 , requested 1 pages during this session, y=3