From my e-mails with Dr. Walsh... by No Unycorns ..... Addisonís Disease Alternatives
Date: 3/15/2011 12:17:23 PM ( 26 mon ago)
His take on AdrenaCalm:
"Regarding AdrenaCalm, it seems to be a good product, though I'm not a huge fan of the company that makes it. For reasons of secrecy, they won't tell people how much PS is in it per dose, but I can tell you I've used it successfully with people in the past, as evidenced by lab testing. I'd rather find a compounding pharmacists to make a batch where we knew the specific dose of PS, but they have more buying power and therefore it's a very reasonable price.
If it were me and I had either high cortisol or an altered circadian rhythm, I'd use both oral and the transdermal to cover all bases."
On the fossilized Lam protocol/Hans Selye:
"The adrenal glands are merely end organs, responding to input by higher order functions, such as the pituitary and possibly even more powerfully, the hypothalamus. The hippocampus and melatonin play a role as well.
The hypothalamus receives inputs from hormones, neurotransmitters and cytokines and using that information, tells other organs to respond accordingly. This whole vitamin C, pantathine, PS, and adrenal tissue is only a stop gap measure and without addressing other factors (beyond stress, perception and lifestyle), many people will continue to be in "adrenal fatigue"."
On a working protocol:
"I'm not a believer in adrenal fatigue per se, but rather that there are signals from other systems telling the adrenals to produce cortisol, or not, and in a particular rhythm.
That being said, it's difficult to say specifically what to do without knowing your entire case, but alpha GPC is not necessarily the first thing I'd chose when trying to correct adrenal issues. Not to say that it is ineffective, but it's one supplement in a much larger picture.
If someone has an altered rhythm (i.e. elevated at night) I consider the following:
1. PS - up to 2 grams per day in divided doses. Transdermal is good, IV is an option (though not very practical).
2. Methyl donors - there are a variety of them. Relatively high doses of whatever you choose.
3. Acetylcholine precursors (i.e. galantamine, Huperzine A, etc) again in a relatively high dose.
Selenium may be indicated as well based on a couple of studies.
Then retest in 30 days to see if there's any change. If not, consider increasing the dose of the above and retest again in 30 days. If there is any change, that's a good sign. Sometimes it can take 6 months to correct so patience is good. If there is no change in 6 months, it's time to re-evaluate things, as the underlying cause has likely not been addressed."
SeriPhos vs. AdrenaCalm:
"SeriPhos is a great product and probably one of the more reliable oral products. You can take it whenever you want, but it can get expensive and, getting upwards of 2g orally can cause some unwanted side effects, something that transdermal creams do not usually cause."
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