first pass metabolism -- does it help a little? by omo ..... Adrenal Fatigue Support Forum
Date: 5/11/2012 4:25:58 AM ( 12 mon ago)
Thanks, Feo for the report. I can theorize all day, but seeing actual effects really helps to materialize a more complete picture.
Here's some more theorizing: Maybe going through the hepatic portal system and going directly to the liver actually does something. The metabolizing to paraxanthine, even if paraxanthine is equipotent to caffeine, could still reduce the adrenal load this way: Normally caffeine first runs around your system exciting you, then it gets metabolized to paraxanthine, which still excites you, then it gets metabolized to less exciting stuff. If caffeine has to go through the liver with coffee enemas, then it may be mostly or largely metabolized to paraxanthine, instead of letting caffeine sit around for a while, thereby skipping a step. That is, the caffeine-as-caffeine phase is shorter or skipped. Reducing the overall time with stimulating substance in the body to mainly the time with paraxanthine, not the standard time with first caffeine then paraxanthine.
So there, if any coffee enema believers want speculation on how coffee enemas might not be as stimulating as one would expect.
But why even bother with any time with caffeine or exciting metabolites of any kind in the body when the effects of a coffee enema are said to be from the palmitic acid?
Maybe as Feo suggests, try decaf. Opt for a low caffeine strain of plant in the first place, get a decaf version of the beans, and dilute it well (as is the protocol for coffee enemas). If you're attached to doing coffee.
Here's another idea: Palmitic acid enemas. Just find a non-stimulating source of palmitic acid. Like maybe palm oil. But I would recommend you dilute it a lot.
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