Schisandra Berry Heals Liver, Raises Glutathione by Quinta_Essentia .....

Schisandra Berry Heals Liver, Raises Glutathione

Date:   2/3/2009 2:26:12 PM ( 12 y ago)

this study showed that a schisandra berrry extract known as schisandrin protects liver cells against toxins and raises glutathione levels significantly. it also says that '(-)Schisandrin B' is more effective than '(+)Schisandrin B' in raising glutathione levels, but i have no idea what that means! apparenlty the negatively charged schisandrin is more potent than the positively charged shisandrin. would you negatively charge your herbs? something to look into.

Effects of Schisandrin B Enantiomers on Cellular Glutathione and Menadione Toxicity in AML12 Hepatocytes

Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, SAR, China

Pharmacology 2006;77:63-70

Effects of schisandrin B enantiomer ((+)Sch B and (-)Sch B) treatment on the reduced cellular glutathione (GSH) level and susceptibility to menadione-induced toxicity were investigated and compared in AML12 hepatocytes. (+)Sch B or (-)Sch B treatment at 6.25 Ámol/l produced a time-dependent change in cellular GSH level, with the maximal stimulation occurring 16 h after dosing. (+)Sch B/(-)Sch B pretreatment for 16 h dose-dependently protected against menadione toxicity, with the maximum degree of protection observable at 6.25 Ámol/l and the extent of protection afforded by (-)Sch B being larger than that of (+)Sch B. The cytoprotection was associated with a parallel enhancement in cellular GSH level in both non-menadione (control) and menadione-intoxicated cells.

While the GSH depletion produced by buthionine sulfoximine/phorone treatment largely abrogated the cytoprotective action of (+)Sch B/(-)Sch B, it almost completely abolished the GSH-enhancing effect of (+)Sch B and (-)Sch B in both control and menadione-treated cells. Both (+)Sch B and (-)Sch B treatments increased the GSH reductase activity in control and menadione-treated cells, with the stimulatory action of (-)Sch B being more potent than that of (+)Sch B in the control condition. (+)Sch B and (-)Sch B also enhanced the gamma-glutamate cysteine ligase activity in menadione-intoxicated cells. The results indicate that (-)Sch B is more effective than (+)Sch B in enhancing cellular GSH and protecting against oxidant injury in hepatocytes.


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