"The Yeast Syndrome" - John Parks Trowbridge, M.D.
The candida syndrome is more noticeable in women than in men. Probably as a result of yeast upsetting the more complex and fragile female hormone cycle. Specific reports, as described in the Dec.1985 Yeast-Human Interaction Symposium research presentation of David Feldman, M.D. indicate that candida albicans can bind to adrenal steroids, apparently producing
adrenal insufficiency. The candida organism competes for adrenal
hormones with the normal cells of a candidiasis patient.
Yeast-related illness also shows up in the disorders of gonads,
thyroid, parathyroid, and other endocrine organs. Addressing the subject of thyroid insufficiency associated with Candida infestation, endorcrinologist Phyllis Saifer, M.D., M.P.H. of San Francisco, current secretary of the American Academy of Environmental Medicine, alerts her colleagues to a unique
medical situation. She cautions that the really difficult to manage yeast syndrome patient often has thyroid trouble, ovarian trouble, both, or some other manifestation of endocrine system exhaustion. For instance, Dr. Saifer stated during a conference in 1982:
"Many patients with environmental illness, in particular those with yeast-connected problems, appear to have thyroiditis. Yet, the physical examination of the thyroid often shows no irregularities and routine T3, T4, and thyroid stimulating hormone (TSH) blood studies may all be entirely normal. Precise diagnosis is often difficult, although measurement of T-ymphocyte cells may help. I suspect thyroiditis in the difficult to manage brittle patient with symptoms of fatigue, depression, chilling,
constipation, irregular menses, and other associated symptoms."
Such glandular dysfunctions as Dr. Saifer described usually respond well to anti-candida therapy.
Candida exhaustion of the endocrine system is not a single disease, but rather the result of differing predisposing aberrations in the victim's immune system - ranging from subtle to life-threatening. Patients with candida endocrinopathies are prone to develop various disabilities, such as:
1. Hypothyroidism, subnormal activity of the thyroid gland, bringing about mental and physical slowing, undue sensitivity to cold, reduced pulse rate, increased weight gai, and coarsening of the skin.
2. Thyroiditis, inflammation of the thyroid gland with an abnormal immune response in which lymphocytes invade the tissues of this endocrine gland (examples of specific disorders are Hashimoto's disease and Grave's disease)
3. Hypoadrenalism, inadequate secretion of the adrenal glands,
characterized by low blood pressure, depression, loss of strength, physical exhaustion and low metabolism.
4. Diabetes mellitus, an endocrine disease in which carbohydrate
metabolism goes awry, with resulting high blood sugars and inability to tolerate usual dietary loads of sugars or starches
5. Hypoparathyroidism, inadequate function of the parathyroid glands, causing a fall in the blood concentration of calcium and, rarely, muscle spasms (called tetany)
6. Pernicious Anemia, a disorder that involves a failure of secretion of "intrinsic factor" (produced in the stomach to enable absorption of vitamin B12 from the small bowel) resulting in defective production of red blood cells.
7. Hepatitis, inflammation of the liver, frequently due to a virus infection because of immunodeficiency
8. Alopecia, loss of hair from areas where it normally grows
9. Vitiligo, a condition in which areas of skin lose their pigment and become whiter than surrounding skin.
During her presentation on Candida, endocrinopathies at the 1985 Yeast-Human Interaction Symposium, Dr. Saifer included these 9
endocrinopathies mentioned above and added 17 more to the list. They are a group of disorders arising from autoimmune dysregulation associated with the Candida syndrome. Dr. Saifer explained that the above conditions, together with the autoimmune endocrinopathies to follow, comprise the "APICH syndrome".
The acronym, APICH, stands for Autoimmune Polyendocrinopathy Immune-dysregulation Candidiosis (the condition of having Candida infestation) Hypersensitivity Syndrome. The complete medical term is a mouthful, and that's why she abbreviates it to APICH. Dr. Saifer added to the exhaustion diseases or symptom complexes of the immune endocrine system that potentially affect candidiasis victims. They are the following (not listed
in the order of their frequency of occurrence):
10. Premenstrual Syndrome (PMS)
11. Addison's disease, a syndrome due to inadquate secretion of
corticosteroid hormones by the adrenal glands, bringing on weakness, darker pigmentation of the skin, loss of energy and low blood pressure.
12. Ooauphoritis (also called ovaritis), an inflammation of one or both ovaries, either on their surfaces or within, possibly resulting from fallopian tube infection or blockage; next to thyroiditis, ooauphoritis is the most common endocrinopathy tied to the Candida syndrome
13. Myasthenia Gravis - a chronic disease marked by abnormal fatigue and weakness of selected muscles, associated with impaired ability of the neurotransmitter acetylcholine to induce muscular contraction, producing temporary paralysis, drooping of the upper eyelid, and double vision
14. Pemphigus - a skin disease marked by successive outbreaks of
15. Allergic Rhinitis - inflammation of the mucous membrane of the nose from allergy, often causing nasal congestion, nasal drainage, or postnasal drainage
16. Schizophrenia - severe mental illness characterized by a
disintegration of the thinking or emotional processes, loss of contact with reality, and emotional unresponsiveness
17. Autism, a severe (psychiatric) disorder of childhood seen as
inability to communicate by speech or to form abstract concepts, repetitive and limited patterns of behavior, and obsessive resistance to small changes in familiar surroundings
18. Sprue, deficient absorption of food due to disease of the small intestine
19. Celiac disease (nontropical sprue), sensitivity of the intestinal lining to the protein gliadin, which is contained in gluten in the germ of wheat, oats and rye, with resulting atrophy of the digestive and absorptive cells of the intestine
20. Idiopathic thrombocytopenic purpura - a deficiency of blood
platelets apparently caused by autoantibodies destroying them, of unknown origin and producing purple skin rashes that are actually bruises
21. Testiculitis - inflammation of the testicles
22. Pituitary deficiency with amenorrhea, the absence of unexpected stopping of menstrual periods because of underfunction of the pituitary gland
23. Systemic Lupus erythematosis, a chronic inflammatory disease of connective tissues, affecting the skin and blood vessels and various internal organs, sometimes showing as a red scaly rash on the face that looks like a mask across the nose and cheeks, arthritis, and progressive
damage to the kidneys
24. Rheumatoid Arthritis - the second most common rheumatic disease, involving acute and persisting inflammation of the joints
25. Sjogren's Syndrome , extreme dryness of the mucous membranes of the mouth and eyes, often seen in menopausal women, associated with rheumatoid arthritis. Raynaud's phenomenon (decreased circulation in the fingers),
and/or dental caries, and can be characterized by purpuric
(bruise-like) spots on the face and decreased function of the salivary glands and tear ducts - often with the need to use artificial tear drops to keep the eyeballs moist
26. Goodpasture's syndrome, an uncommon hypersensitivity disorder of unknown cause, manifested by lung hemorhage (bleeding) with severe and progressive inflammation of the kidney tubules, eventually leading to kidney failure.
"All of the above 26 conditions of APICH syndrome are autoimmune
diseases in which antibodies to 'self' can be demonstrated", Dr. Saifer said. They are systemic autoimmune problems, and a distinct relationship to the Candida Syndrome appears likely.
"The Yeast Syndrome" - John Parks Trowbridge, M.D. and Morton Walker,