My aunt had very bad MS, but then she also went the medical route. I live (as did she) in SE Michigan. A doctor I used to work for said he read that it is more prevalent along the Ohio River Valley, for reasons unknown - genetic and families staying in the same area, or maybe something environmental? There is probably more lack of sun here than, say, in Southern CA, but it's not like Seattle. I am a lot happier since I started this cod liver oil, kelp, minerals protocol. I feel much less tendency toward depression. Probably IS the D, though I think the Iodine in the kelp is a factor, as well.