I would start slow, it doesn't cause diarrhea in low doses. When you get to 2 drops 2x a day. Hold there a bit. You may find that your diarrhea goes away due to the charging of your immune system--then you can take less Immodium. Then increase as you can. That is something Jim mentions a lot is that it "supercharges the immune system." Of course it kills all of the pathogens which are probably involved in your condition also. Some people stay on low doses for months. It is still very powerful.