You ask a very good question and something to contemplate!
Here's my take on it: I believe that this depends on the prevalence of each of the co-factors calculating how each could possibly react. Since the body is in an imbalance state, but balanced within, with each co-factor, attacking one without affecting the others could be tricky. If you could look at it like a stack of dominoes it might be helpful; each co-factor is color coded with a set of dominoes. One little flick of the finger can send the stack tumbling. The tumbling of dominoes could be orderly where they topple neatly with great precision in a coordinated fashion. If you don't understand how the dominoes effect works the stack could fall into disarray in a confused mess, or some dominoes get hit and others missed. Perhaps the ones that get hit/missed would suffice for the time being.... hard to say.
Somewhere on the P Forum there is a post by Apxr on his research and studies. If I recall correctly, he mentioned that for parasites it was best to start off in small doses to keep the parasites where they are and comfortable; this also helps with keeping a balance in the body. Then follow-up later with hitting them hard with large doses, then back down with small doses again and later up the dosages. In other words, attack slowly and aggressively, retreat a little, and attack again. I think that post was started by Megan on "Maybe we're living in hell" or something like that. The strategy seemed to make some sense; fighting parasites is war and the tactic seems to be war-like as an approach.