Chelation therapy became a popular "alternative" treatment after EDTA was found effective in chelating and removing toxic metals from the blood, and some scientists postulated that hardened arteries could be softened if the calcium in their walls was removed. The first indication that EDTA treatment might benefit patients with atherosclerosis came from Clarke, Clarke, and Mosher, who, in 1956, reported that patients with occlusive peripheral vascular disease said they felt better after treatment with EDTA.
Carnosine, as a dietary supplement, seems to have all the same chelating properties as EDTA, and it offers a possibility for an inexpensive oral chelation therapy.