I think that the poster asked for proof, not anecdotal, and not from a third party. And Tom, what about the potential for problems with the bone marrow in long term use. That seems pretty serious to me. Also, the potential for damaging red blood cells. If the potential is there, if it has been seen in small studies, then it isn't safe to take it until it is known. For all of those that are claiming that it is safe now, what will they find in one year, five years? Humble doesn't know, and I find it hard to trust the judgement of someone who makes wild claims, and then changes them as he sees what it is doing to people. A responsible person would find the answers before making the claims. Until the mechanism of how it works in the body is known, it isn't safe.