No supplement will affect lipomas (fatty tumors) and they will continue to grow, only surgery will remove them. Depending on where they are, they can cause problems with walking or put pressure on other organs, causing dysfunction. Also, as already mentioned, they can get infected or necrotic, causing more heath problems.
A friend's Labrador had multiple, large lipomas on his chest/armpits (causung walking problems, and being able to sleep very uncomfortably), along with internal ones. She insisted on treating him with supplements and refused to consider surgery until he collapsed from toxin build-up from the pressure on his bowel from one of the internal tumors.
Surgery was performed, and a 6 pound lipoma was removed from around his bowel. In addition, a 3# one was removed that was pressing against his liver. The 3 chest tumors were each 2#.
He recovered well (with his new, svelt figure), and had increased energy and normal mobility. Today, hes's still active, and has resumed being a trail dog at a local stable.