I can't tell you exactly what it does to age you prematurely. But I can confirm it from personal experience. I went from a fairly good-looking thirty year old who was always told she looked much younger than her age, to having someone assume I was over age 45, all within a year. I know the "aged" look comes and goes, depending on how well I feel, but I've never gone back to truly looking my age or younger again. Not since this whole thing started. I believe it can be reversed.