It would seem that if herx reaction was a result of oxidative stress it would affect one person about the same each time they took it or even getting worse as the protocal pregresses as the effects of oxidative stress would be cumulative. the opposite seem to be true however. A person seems to be able to take more over time and not less. another point would be that there seems to be a wide range of drops that product the herx like symtoms in people. i now people who can hardly take a drop and other who can start with 15 drope with little if any herx reaction. There might be an individual reaction to oxidative stress but i don't think it would manifest over such wide range of dosages.