Absolutely!! I have suffered with headaches for years. I would go for weeks at a time when I would get a headache almost every day. I never made the connection until after my first flush. I went for weeks without even a hint of a headache. Then they returned along with my gallbladder pain. I keep doing flushes and each time the gallbladder pain and headaches become less severe and less frequent. I knew I had to do something about my gallbladder attacks but the bonus of getting rid of headaches was a miricle to me!!