???? I don't know, but I'm not a doctor/naturopath either... Also I have been on candida cleanses where I haven't experienced any die-off and that's before I discovered liver flushes, so maybe it just depends on the anti-fungals and their "harshness"? But regardless of why you don't have it, NOT having die-off is a GOOD thing! It means your liver can handle the toxins that candida produces so GOOD JOB!!