I seen this online about the connection between mercury and adrenals:
- Mercury accumulates in the adrenal glands and disrupts adrenal gland function.
- Mercury builds up in the pituitary gland and depletes the adrenals of both pantothenic acid and vitamin-C. Stress and the presence of mercury will have a very negative effect on the adrenal production of critical steroids.
- Adenylate cyclase activity in the brain is inhibited by micromolar concentrations of lead, mercury, and cadmium.
- Mercury causes a defect in adrenal steroid biosynthesis by inhibiting the activity of 21a-hydroxylase. The consequences of this inhibition include lowered plasma levels of corticosterone and elevated concentrations of DHEA and progesterone.
- Because patients with 21-hydroxylase deficiencies are incapable of synthesizing cortisol with normal efficiency, there’s a compensatory rise in ACTH leading to adrenal hyperplasia and excessive excretion of 17a-hydroxyprogesterone, which, without the enzyme 21-hydroxylase, cannot be converted to cortisol.
- The Inhibition of the 21-hydroxylase system may be the mechanism behind the mercury-induced adrenal hyperplasia.
- Both lead and mercury can precipitate pathophysiological changes along the hypothalamus-pituitary-adrenal and gonadal axis that may seriously affect reproductive function, organs, and tissues.
- Mercury not only causes a suppression of adrenocorticosteroids that would normally have stimulated an increase of PMNs, but at the same time also affect the ability of existing PMNs to perform immune function by inhibiting a metabolic reaction that destroys foreign substances.