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Published: 11 years ago
 

The REAL half-life of DMSA


Andy keeps saying that DMSA and ALA dissipate in your body at about the same rate, and that after three hours both are pretty much gone

Absolutely not true.

Remember, the term half-life refers to how long it takes for 50% of any substance to dissipate. So if substance X as a half-life of one hour, and you take 100 mg of it, that means after one hour 50 mg will be left

In order for a substance to dissipate in three hours, it's half-life would have to be 30 minutes. Let's say you take 100 mg of something, after 30 minute 50 mg is left, after one hour 25 mg, 1 1/2 hour 12.5 mg left, after two hours about 6 mg left, after two and half hours 3 mg left, finally after three hours there is only 1.5 mg still active

now the half-life of ALA is in fact about 30 minutes.

However!

The half-life of DMSA is definitely not 30 minutes as Andy claims it is. Just do the research if you don't believe me. The half-life of DMSA is between 2.5 and 3.5 hours

look at this chart. The yellow line shows actual blood levels after one dose of DMSA. note that it takes about seven hours for there is a minimal amount of DMSA left in the blood. even after six hours there is still a considerable amount present in the blood


http://ehp.niehs.nih.gov/realfiles/members/1995/103-7-8/asiedufig3a.GIF


this is the study I got that graph from

http://ehp.niehs.nih.gov/realfiles/members/1995/103-7-8/asiedu-full.html


Here is the Wikipedia entry

http://en.wikipedia.org/wiki/Dimercaptosuccinic_acid


Dimercaptosuccinic acid (CHEMET) is indicated for the treatment of lead poisoning in children with blood level measured above 45 µg/dL. The use of DMSA is not approved for prophylactic/prevention of lead poisoning in anticipation of exposure in known lead contaminated environments.

***Its elimination half-life is 2.5-3.5 h.***

DMSA can cross the blood-brain barrier of mice,[4] but not that of humans, limiting its use to extracting heavy metals from parts of the body other than the central nervous system
 

 
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