With the valacyclovir that is used to supress the herpes, and it works but I've only been on it for a day. I have a 2 week regimen of it but he said that length of time is just for certainty purposes, not taking two weeks to get it out of the cells. And no, the cold sore that came up and triggered the wart virus to come back had become a scab, and it was hard to tell in the picture because it was a brownish skin colored scab on the top of my upper lip. But when the scab fell off after I was done with the zyclara, there was still tingling and redness (which is not uncommon for cold sores to do that even after they've scabbed, already confirmed that with dr.) So I went back to see him and the conclusion was that if the only difference between being treated last time and this time was the presence of the cold sore, then the only obvious plan of action is to get the herpes virus out of cells and back into dormancy so that there is no possible way the wart skin can survive the treatment again. Does that make sense? Its a lot to explain and sounds like a stretch I know, but it makes perfect sense considering that if my trigger was still active after the zyclara had run its course, the skin was still fair game to the virus to come back because its cause had still not been eliminated. It was a first for me hearing that could happen, and again this is my own personal case, if you don't get cold sores it obviously wouldn't apply to you.