Take care of intestinal parasites, and all this may fall into place for you. I have been researching MTHFR gene mutations for a while now......not one of the sufferers that I personally spoke to of this "gene mutation" have not had parasites.....so rather than concentrate on the gene issue, and having a reason for the detox issues, I choose to look at what may cause the mutation to show up in tests, just as in mineral imbalance......just throwing it out there......look at your gut issues before the "why and how" to a possible gene mutation. The parasites that inhabit our gut can lead to false DNA testing, which is something else we have all been led to believe is not possible!!