What drove you to take high dose probiotics and what do you consider high dose?
The one I use is 50 billion cfu’s PER CAPSULE and I take 2 a day after some time loading and never had any problems. That being said, we are all different.
If you started probiotics because you think/know you have intestinal issues then those issues could be the source of many of your ills.
Many intestinal pathogens decrease the bodies ability to absorb nutrients and can actually alter the PH of the gut and increase heavy metal retention.
Genova diagnostics has a very thorough stool test for identifying intestinal pathogens that runs around $300. It may be worth a shot to help you precisely identify what you have so you can target it.
Probiotics are great but they alone wont really get ride of pathogens and can generally on take hold if there is room for them. In guts that are already overcrowded with bad bacteria there isnt any place for the good to take root.