We are on our second round of Humaworm. Currently only day 3, but I took DE for a month in between cleanses to help ease my mind. I read somewhere that it was a good idea to use it two weeks AFTER you take humaworm to help get everything out, but I would be curious to see what anyone says about taking both. I would imagine you would want to hold off as it has binding properties to it, and you wouldn't want the DE to bind to any of the herbs while taking it. That is just my guess.