I can only tell you my experience, everyone is different. I drank about 8oz with some apple cider vinegar in it, only because i liked the taste of it better, iat one sitting for five days and it didn't work. Then I drank it another 10 days and ate an organic apple every day. Total success. So 15 days of a glass of apple juice and I got stones 7/8 inches, almost 22mm in diameter. I was really blocked for a long time and had almost given in to surgery b/c all recent flushes didn't work and were making me very nauseous. My ND told me just to drink it a long time ago, no specific instructions, either. That was long before I was so blocked and didn't need the extra help. Good luck!