Both I and one of my sons get an excema if we ingest even tiny amounts of sweeteners. As chewing gum. We are lucky because we found out early on, when I was pregnant with him, and used sweeteners in a stupid attempt to avoid putting on too much weight. It caused a severe pregnancy itch, that is related to preeclampsia. Problem with it, is that some people seemingly tolerate it fairly well, or that the symptoms dont show up in a way they can relate to the sweetener.
First thing I told the health cases I worked with; stay far away from it!
Several of them had Aha- moments when they quit it.