A 30-year-old patient with small bowel Crohn’s disease diagnosed 3 years ago came to the outpatient clinic complaining of amnesia in relation to familiar names, for the last 2 years. Physical and neurologic examination were both negative. Laboratory tests were within normal limits. Anti- cardiolipin antibody, lupus anticoagulant, the widely known list of risk factors for ischemic stroke, possible sources of emboli such as carotids and heart, deficiencies of protein C, activated protein C, protein S and antithrombin III lead- ing to hypercoagulation were negative. Circulating immu- nocomplexes and p-antineutrophil cytoplasm autoantibod- ies (p-ANCA) were not detected.Neurological examination revealed amnesia and brain magnetic resonance images (MRI) showed cortical atrophy and a focal lesion in the paraventricular deep white matter of the left frontal lobe.
This is, to our knowledge the first report of a young CD patient with amnesia and MRI demonstrable brain atrophy with focal white matter lesion.