Depends on the anatomy, and everything has to be oiled to the max, and go very very slowly, must be able to totally relax. If the owner of the hand is patient and skillful it can be rewarding, there are two primary hand formations, motions, and rhythms that can elicit spasms from the Skene's glands, resulting in a "squirting' that provides a very satisfying and intense release from the female side. Most women are not open-minded to even think about this, but some are and they get their reward, with afterquakes that last for several hours afterwards.