The effect of fungal candida on the ratios of different bacterial colonies present in the intestinal tract, can create imbalances that cause leaky gut, increased systemic inflammation, diabetes, and many other imbalances.
If you read backward into this study, you see that diabetics have intestinal flora ratios that lead to decreased production of short-chain fatty acids. Decreased production of fatty acids, like butyric and propionic acids, is associated with leaky gut, insulin resistance, inflammation, obesity, and autoimmunity - conditions that cause diabetes.
While this study cited beneficial effects on the bacterial flora via increased short-chain fatty acid production, it also cited negative side effects on the intestines from metformin. These frequently include diarrhea, vomiting, nausea, bloating, flatulence, indigestion, abdominal discomfort, loss of appetite, and others.
Restoring balance to the bacterial flora via correcting fungal candida imbalances is a better way to approach restoring health than through the use of drugs with hundreds of known side effects. For the most effective way to restore a healthy intestinal tract - http://www.candidaplan.com.