A skin biopsy won't cut it. It has to be a punch biopsy. I even accused my dermatologist of faking a biopsy on me just to fulfill my request. She admitted that the specimen she took was shallow, and of course it came back negative.
I had a punch biopsy in 2012. It was a fresh lesion, never touched, never scratched open, and it was positive for arthropod activity and full of eosinophils.
Still--guess what--I am considered delusional, because the doctors can't find the pathogen, CAN'T CURE IT, and are deficient in knowledge and void of curiosity.