Hi zoom, this happens to me to! I just can't figure out why because overall MT does make me feel better but then that nasty fatigue with my legs feelings like logs. This could be for a few reasons, I think... 1. MT is a sulphur source and I have CBS gene mutation, perhaps it overwhelms the pathways somehow. 2. Perhaps it slows or speeds phase 1 detox but we need something else to counteract that with phase 2. I may have to try NAC as NAC seems to boost phase 2. If anyone can shed any light on this it would be great!