Thank you for your message. Yes I have been takeing probiotics on and off for years, to no avail. However I have been taking threelac for a week now and have noticed a lot the dreaded candida strands passing through me (which is good I know) I have been feeling awful though and it has brought on another Iritis attack which I'm thinking may have been caused by the die off of the Candida. So perseverance is a must! I have had two colonics and although they are helpful to find out from a qualified person what is coming out (it is how I found out I had candida) I find them quite uncomfortable(although not painful) and quite slow in taking effect. Do not expect immediate results, I think you will need a series of them. So I switched to taking Oxypowder , which is excellant in getting rid of the muciod plaque but was not so successful with the candida; so taking it with the threelac is quite effective. I always considered my diet to be healthy. I am reluctant to start living on raw food, but if I have no improvements to what I am doing at the moment I will start taking that route.