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Re: What is IGA?
Mr. Tee Views: 1,348
Published: 15 years ago
This is a reply to # 302,396

Re: What is IGA?

"Secretory IgA (immunoglobulin A) is the predominant antibody or immune protein the body manufactures and releases in external excretions such as saliva, tears, and milk. It is also transported through the epithelial cells that line the intestines out into the lumen. Secretory IgA represents the first line of defense of the GI mucosa and is central to the normal function of the GI tract as an immune barrier. As the principal immunoglobulin isotype present in mucosal secretions, secretory IgA plays an important role in controlling interstinal milieu which is constantly presented with potentially harmful antigens such as pathogenic bacteria, parasites, yeast, viruses, abnormal cell antigens, and allergenic proteins. Secretory IgA antibodies exert their function by binding to antigenic epitopes on the invading microorganism limiting their mobility and adhesion to the epithelium of the mucus membrane. This prevents the antigens from reaching systemic circulation allowing them to be excreted directly in the feces."

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