You need to take the #1 first and get your bowels moving regularly. While you are doing the #2 cleanse you will get bound up if you do not take a couple of extra #1. If you have been constipated for some time you really need to do the #2--especially if it has been a chronic thing throughout your life. Being constipated pushes old fecal matter back into little pockets and it just sits there and rots and can cause disease. Taking the #2 will vacuum all of that crud out of your bowels and also out of your appendix, and you'll feel much better. My mom lost 15 pounds of fecal matter her first Colon Cleanse with the #2!! Now who wouldn't love to lose a few extra pounds and get rid all that crud in your gut? If you have a round belly you'll be amazed at how much this helps flatten it out too. So there is both cosmetic and good health reasons to take it. ;) And it is soooo easy, you just drink the powder five times a day for a week till the container is gone. What could be easier and do this much good for you to??