I have been having one P+B shake a day for the last month. I don't really want to increase the amount I have as I am happy with the results and to be honest, I don't really have time to as I am not at home very much. I have my shake not long before I go to bed as I know my stomach will be empty by this time. Obviously drinking a substantial amount of liquid before I go to bed is likely to make me wake up and need the toilet. However, I am always surprised at how much urine I actually pass, as it seems to be huge volumes. Normally I wake up a couple of times during the night to pee and also have a full bladder when I get up in the morning. Does P+B also affect the kidneys as well as the colon? I haven't read anything that says it does. Any comments would be appreciated!