i have taken the high dose of CoQ10 on 3 seperate occasions at a 6 mo. interval... i opened the capsules and poured the contents into a tablespoon of honey that i'd softened in the microwave... mixed it up and ate it... i didn't hate it! ... anyway, no ill effects... sounds a bit scary to take such a high dose of anything, but it didn't bother me at all... in fact i'm due for another session of this myself!