The liver is the main blood cleansing organ in the body, and without open bile ducts the other organs of elimination are not going to be very efficient either. Every cell in the body depends on the liver and its ability to break down and remove noxious substances, including metals. Also the see the explanations on this on my website or in my liver cleanse book. To achieve a breakthrough, though, the bile ducts must be completely cleaned out, which doesn't happen just by doing one cleanse, although symptoms may improve. When the liver isn't effcient, cleansing attempts of other organs can increase the incidence of cleansing reactions. So, liver cleansing may be the missing link for you.