Actually yes I did apply it directly and I did get very beneficial effects though I stopped using it cause it started smelling terrible and I think it went bad because the same time it smelt terrible was when it started losing effect. So I just ordered another one... and well I am look terrible today but I know it's from toxins I just now it and it could be from spine missallignment also... but hopefully by the end of the week I'll find out which... because my first Liver Flush I looked astonishing and that was over a week ago... I suppose you have to wait longer than that even though I'm thinking of pulling forward with it because it just seems like my body is crying out for it. But I also go to chiro for allignment on wensday and hopefully that'll have a positive effect on alot. But basically just apply it directly and chill in the bathtub or shower or apply it right before you sleep.