Studies of this type won't be available through the US Government or any other agency. Would you want to be the bureaucrat responsible for costing the doctors and pharmaceutical interests billions? Compare the so called toxic effects of Splenda with other yeast treatments and the die off symptoms caused by them. They are the same, identical. I experienced die off symptoms while using Fruit2O, made with pure sucralose, three years ago. Then I used known, yeast killing, herbs and plant extracts. I was able to see a pattern. I began using more Splenda and I killed off more yeast. Sucralose is the best killer of yeast and doctors know it.