I am on 120 mgs -- which I break up into three doses (7:45, 1 p.m. and 5 p.m.). Those three doses I break up further. I put 1/2 of a dose under my tongue and the other half between cheek and gum at the bucal gland.
I personally feel that if your T3 level is not optimal, you won't lose weight. Body temp is a good indicator to follow. Mine is always 96-97.9 except maybe once a day it goes up to 98.6.
TSH is not a good measure of how you are doing or whether you are taking enough because many of us have resistance and have to take a little more than a TSH level would indicate.
My ND told me 'ignore tests, go by how you feel and look', and I feel and look so MUCH better! (my face/neck especially), and mentally feel awake since changing how I take these meds. The goiter I had for years has disappeared in the last 3 weeks.
I went through 2 weeks of severe depression/extreme fatigue until I learned that some people react that way to Calcium, and as soon as I got off the Calcium,
I felt good again.