twice a day, and that is when I take the herbs. The vitamin C and needs to be taken an hour either side of the Iodine - I usually take the other vitamins and minerals then. The salt push can be taken whenever you like. Optimum seems to be a while before taking the iodine. I take the IP6 all by itself with water, a few hours after or an hour before anything else. Some folks take Iodine all day long.. in their water. Others apace it out to two or three doses. Some take it once daily.
You will figure out what works best for you very fast, I sure did.