You can add B5 (if you take it with phosphatidyl choline it adds muscle tone, take equal amounts of it and B5). It has been used for arthritis for a long time. it is safe in high amounts. don't get timed release. Take like 500 to 1000mg 4 times a day or you can start out with 500mg 4x/day and see how that works, increase as needed. It wears off in 2 to 3 hrs. You will be able to tell when it wears off. I used it many years when I had fibromyalgia and other arthritis pain.
An increased susceptibility to infections, fatigue and decreased ability to cope with stress could indicate a deficiency of pantothenic acid. This important B vitamin has been shown to help in wound healing, arthritis, building immune antibodies and lowering the toxicity of many antibiotics. Like many other cardioprotective and energy-enhancing compounds, pantothenic acid also appears to protect against cancer. It even helps remove lipofuscin, the ugly brown pigment in "age spots." More importantly, though, is the fact that the brain uses pantothenic acid to transform choline into acetylcholine.
*iNOS (inducible nitric oxide synthase) is dramatically upregulated in inflammation, and the overproduction of NO can play a role in cell death. See Sedlak and Snyder. Messenger molecules and cell death. JAMA 295(1):85 (2006). We would expect that the choline and vitamin B5 that we have in our arginine formulation would mitigate this, because acetylcholine is anti-inflammatory as well as stimulating desired eNOS (endothelial nitric oxide synthase) activity.