I tend to increase or decrease Lugol's according to how I feel. I have to work and cannot afford to make myself sick, no matter how helpful it might prove to be in the long run. If your instincts say decrease the dosage, then do so. If you feel the salt push will help, do it. I don't mean to sound wishy-washy, but we have to trust our instincts when it comes to this kind of therapy. The good thing about this is even with very small doses we are helping ourselves. Whether you take one drop or twenty, use your judgement and take what you can tolerate without pain or discomfort. I firmly believe its better to moderate and adjust your doses rather than forcing yourself to suffer and then give up too soon.