What has worked for me after trying many others is colonix by drnatura. This cleanse was easy to take, didn't have to adjust my life around it and was gentle on my system. I initially started with a 3 month cleanse. Others I've tried were 7 - 14 days long and I had severe reactions. I would have the runs or I would be constipated. But I would also recommend you seek a naturopath who can put you on the track of eating right for your body. It has helped me tremendously while incorporating the colonix program at least once a year.
Let us know what you decided to use and what is helping you.