I am taking 8 horizontal drops 3 x a day. I take it in juice, though I tried it the first night in water just to check it out. I was taking my Lugols in juice (mixed with water almost half and half) also. The Wilson's seems smoother. Sometimes with the Lugols I can tell when it hits my stomach. So far I haven't had that experience with the Wilson's. Also, so far no side effects or detox reactions. I have always taken the Lugols with vertical (vs horizontal) drops until this last week. So using 8 horizontal drops per dose of the Wilson's is a big dose for me. No headache and I am not using any doses of salt. I am taking 5,000 mg of homemade sodium ascorbate per day.