Re: no cataract research allowed - by order of the health ministry! by tke ..... Cataract Forum
Date: 10/3/2017 9:14:43 PM ( 6 years ago ago)
Yes, of course I know about Professor Steven Gallant. We have found that his carnosine eye drops (which are sold online today) do reverse cortical cataract, but not nuclear cataract deep in the inner layers of the lens. Carnosine acts by "sacrificing" itself in order to spare lens proteins from further photooxidation, and it can also break some bonds between AGEs (Advanced Glycation End-Products) and lens proteins, but since it is a dipeptide (a protein component), the result of this "sacrificial act" generates metabolic waste just like the proteins in the nucleus themselves. This means that if those waste products are colored chromophores which are obstructing light from getting through the lens, carnosine will generate more of them and worsen the cataract. It does however seem to clear the lens if the cataract is very early.
The only way of clearing the damaged proteins out of the nucleus is for the epithelial cells on the front surface of the lens to recognize them as damaged, and gobble them up. This is actually happening all the time in a normal eye: cataract is disappearing as fast as it forms. But the levels of the two 'signaling enzymes' (Ubc4 and Ubc5) in the inner layers of the lens, which "tell" the epithelial cells about the damaged proteins deep in the core of the lens, decline as you get older (published research). And this is exactly why so many of us eventually get cataract: the signal is lost. The good news is, the epithelial cells could still clear the lens if those two enzymes were re-supplied as eye drops, or orally. The bad news is, the eye profession doesn't want to do it.
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