Biopsy results 
goldstander
11 y
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This is what the report said :
- This lip biopsy has non-keratinising squamous mucosa with mild and irregular acanthosis, there is no spongiosis or lichenoid inflammation. Around upper dermal vessels there is minimal lymphocytic infiltrate with no evidence of 'granuloma' formation. however there is an obvious diffuse accumulation of acidicmucopolysaccharide ( alcian blue positive ) both between collagen fibres and extending down in and around muscle bundles. There is no associated fibroblastic proliferation.
Comment :
- if this is a diffuse process confined to the lip and not associatedwith mucocoele then one of the focal mucinoses should be considered including reticular erythematous mucinosis ( REM ).
Conclusion
lower lip swlling Punch biopsy - see comment.
So from what i understand there is no inflammation right ?
Also, when i searched up mucinosis, i found this definition :Mucinoses are a group of cutaneous diseases caused by fibroblasts producing abnormally large amounts of acid mucopolysaccharides (i.e. mucin), usually hyaluronic acid.
Again, I remember talk about hyaluronidase turning off fibroblasts thus, if this is the problem, ec should reside with the injections right ?
Anyway, what do you guys make of this ?
Now that ive finally got my results, ive booked an appointment with this doctor - http://www.westbournecentre.com/hiroshi-nishikawa
as he was recommended to me for wednesday. so lets see how that goes.
anyway thoughts on this would be appreciated.
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- Re: Biopsy results Ibinns
11 y
2,790
MoreThis is a reply to # 2,091,035I kept bringing up the fibroblast situation and based on your results it seems like my theory was in the right direction. I have posted about it before. The fibroblasts are definitely functioning irregularly and the hyaluronidase injections turns them off (allowing a cellular memory reset as well) thus allowing the hydrocortizone & neomycin to penetrate the region of concern & treat it. Then, when the fibroblasts are activated again, they don't see a problem anymore so they resume their normal functions. This ties in with the cellular memory effect other members here mentioned.
I really wish for someone to just try the hyaluronidase injections followed by the 1% hydrocortizone/neomycin ointment already. It is by far the most promising treatment I have seen with a high cure rate and zero to no side effects. I am SO willing to try it but, like I mentioned before, doctors here in New York just know a money sucking opportunity when they see one.
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- Re: Biopsy results longterm
11 y
2,705
This is a reply to # 2,091,035The injections are worth a shot. The reason I tried Iodine solution on my lips was to turn off the fibroblasts. I think the injections would be effective since they can go deeper into tissue as well as absorb the ointments better.
Your biopsy report stated, "minimal lymphocytic infiltrate " This mess not many lymphocytes are present. An immunologist should know if this is normal or not.- Re: Biopsy results goldstander
11 y
2,681
This is a reply to # 2,091,093guys thanks, seems promising.
What seems odd to me, is that they are saying I have no inflammation right ? Isn't flammation one of the keys of ec....
Moreover, yes, ill be getting the injections done soon, will bring up with the doctor on wednesday.
And ill also discuss the lymphocytes with em'm
- Re: Biopsy results goldstander
11 y
2,681
- Re: Biopsy results Bradbutter
11 y
2,772
This is a reply to # 2,091,035Here is a question that bothers me after the results why didn't you ask the doctors these questions instead of coming on curezone and asking us. We dont know. Ask the doctors man does EC make you a little slow in the brain. Dude when I got my results which showed nothing I still asked a million questions to the doctors.
- Re: Biopsy results goldstander
11 y
2,651
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This is a reply to # 2,091,100You f***ing idiot, I got this printed from my doctors nurse. Am sure she hasn't got no clue whatsoever a word of it meant. Hence, why am taking it to a doc this wednesday.
Why not just go f***yourself, and feel pity yourself a bit more bradbutters- Re: Biopsy results Ibinns
11 y
2,777
This is a reply to # 2,091,104Man, that's kinda harsh goldstander. But anyway, remember that EC can also be triggered from allergies, & infections. Whether allergies and infections cause inflammation in the lips is unknown to me. But what I do know is that your results mentioned the fibroblast theory that Longterm's finding of a 1950's article mentions so, it adds a hell of a lot more credibility to the article.
I will post the link to the article in this thread for ease of locating it. Special thanks goes to Longterm for finding it.
http://www.nature.com/jid/journal/v26/n5/pdf/jid195645a.pdf
- Re: Biopsy results Ibinns
11 y
2,662
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This is a reply to # 2,091,113I couldn't help but to shed a bit more light on some of the medical terms used in your biopsy. I really hate medical jargon, but I rather have legible medical jargon as opposed to the sloppy ass handwriting some doctors have.
Squamous - having the body covered or partially covered with thin horny plates, as some fish and reptiles.
Acanthosis - An abnormal but benign thickening of the prickle-cell layer of the skin (as in psoriasis).
Granuloma - A tumor composed of granulation tissue resulting from injury, inflammation or infection.
- Re: Biopsy results Ibinns
11 y
2,662
- Re: Biopsy results Ibinns
11 y
2,777
- Re: Biopsy results goldstander
11 y
2,651
- Re: Biopsy results Nousername
7 y
2,333
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This is a reply to # 2,091,035Sorry for the 4 year bump.
I've had my biopsy results return and I have the same result. The diagnosis from the pathologist who examined the biopsy says "lip mucinosis".
When I asked my dermatologist what the hell that is she described something like the reticular erythematous mucinosis. Apparently it's quite rare and tomorrow I'll be going to be examined by a group of doctors who will decide how it should be treated at the same hospital.
Apparently it's quite rare.- Re: Biopsy results longterm
7 y
1,899
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This is a reply to # 2,351,686Since mucin is produced by fibroblasts, it seems the best treatment would be one that decreases fibroblasts.- Re: Biopsy results Nousername
7 y
2,243
RN Educational
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This is a reply to # 2,351,725Anyway, I'm back from the hospital. The consilium (not sure how to translate it) of doctors there really tore my dermatologist apart and instead proposed it was just an allergy and it was natural for mucin to be inside the lips (not sure about that but whatever). Their proposal was for me to use antihistamines, which I've told them I've used for a year straight, despite all allergy tests being negative etc. I am to come back there in 1 month.
Feel bad about my derm. She really tried to bring out the whole mucin issue to her colleagues but they're a bunch of a-holes.
My derm originally prescribed Elidel (pimecrolimus) twice a day for the mucinosis, but I've already tried it for a month before with a different doctor and I guess there was maybe some progress, though they really need to be moisturized constantly. That's why I was referred to a group consultation in the same place by her.
I guess I'll try a few months, instead of a few weeks, of Elidel and see how it goes.- Re: Biopsy results Nousername
7 y
1,840
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This is a reply to # 2,351,807Here are the important parts of my biopsy results. I translated it to the best of knowledge.
Skin biopsy 0,2cm
Microscopic description:
Lip biopsy shows visible uneven hyperplasia of epidermis, subepithelial layer mucinosis, very slight perivascular and interstitial lymphocyte infiltratation.
Clinical Diagnosis:
Lower lip cheilitis, urtcitaria, lip mucinosis
Final pathological diagnosis:
Changes seen in the biopsy are compatible with lip mucinosis diagnosis- Re: Biopsy results CrustNoMore
7 y
1,815
This is a reply to # 2,351,808Sorry for the bump. I found these results very interesting.
I have tried hyaluronidase injection because my EC was caused by (or made much worse by) dermal filler injection (hyaluronic acid ). Hyaluronidase dissolves hyaluronic acid filler.
The hyaluronidase definitley did help (but , then I had artificial hylauronic acid in my lips). However, what I noticed was that the hyaluronidase injections made the peeling much more intense for a day or so (I attributed this to the swelling and inflammation caused by the injection ).
Ultimately it didn't stop the peeling.
- Re: Biopsy results CrustNoMore
7 y
1,815
- Re: Biopsy results Nousername
7 y
1,840
- Re: Biopsy results Nousername
7 y
2,243
RN Educational
- Re: Biopsy results longterm
7 y
1,899
- Re: Biopsy results Ibinns
11 y
2,790
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